The elastic modulus of cancellous bone is derived based on the measured elastic properties of separate mineral and protein phases. Adopting the mechanics of cellular solids approach, the moduli of elasticity of cancellous, deproteinated and demineralized bone are expressed in terms of the trabecular moduli of elasticity and the corresponding density ratios using the power law expressions. The Y...

The penetration characteristics of piperacillin-tazobactam into cortical and cancellous bone tissues were investigated in 10 patients undergoing total hip replacement. The concentration ratios of piperacillin/tazobactam were 9.4 +/- 1.8 in cancellous bone tissue and 8.0 +/- 2.2 in cortical bone tissue, which were close to the 8:1 ratio of drugs administered. The mean ratios of drug concentratio...

Research in cancellous bone has grown exponentially over the last 20 years and is still going on. The knowledge of the mechanical properties of cancellous bone will enhance the understanding of bonerelated fracture. Cancellous bone is a highly porous or cellular form of bone. Unlike most metal properties, cancellous bone is non-isotropic and its mechanical properties (elastic modulus, yield str...

OBJECTIVES The question has been raised whether benign bone defects in patients can be treated with bone forming osteoconductive ceramics achieving primarily a cancellous bone scaffold, which is under load from the beginning. MATERIAL AND METHODS Ten reconstructions were performed in 9patients (6women and 3male), with a mean age of 49 (25-65)years, suffering a high variety of epi- and metaphy...

Objective- To evaluate tail vertebra as an autogenous cortical bone and cancellous bone for filling ulnarsegmental bone defect in dogs.Design- Experimental study.Animals- Eight adult mongrel dogs with an aver age age of 37.S months and average body wei ght of17.62 kg.Procedure- Th e animals were randomly divided into two groups . A bone defect (2.S-cm) was created onthe middle po rtion of the r...

OBJECTIVE To determine the concentrations of lead (Pb) and cadmium (Cd) in three kinds of materials (cartilage, cortical bone, and cancellous bone) of the femur head obtained from patients in the process of operation. METHODS Concentrations of Pb and Cd were determined in selected parts of the femur head of 30 patients after total hip arthroplasty, using ICP-AES (atomic absorption spectrophot...

Background and purpose - Studies of fracture healing have mainly dealt with shaft fractures, both experimentally and clinically. In contrast, most patients have metaphyseal fractures. There is an increasing awareness that metaphyseal fractures heal partly through mechanisms specific to cancellous bone. Several new models for the study of cancellous bone healing have recently been presented. Thi...

OBJECTIVE The present study addresses the question--can PTH induce formation of trabeculae in areas where cancellous bone has disappeared? Two-year-old male rats were chosen, because in this aged animal model the distal femurs have almost no cancellous bone, and the marrow cavity has reached a substantial dimension. DESIGN The rats were injected for 56 days with either PTH(1-34), 15 nmol/kg/d...

Aim: Mesenchymal stem cells (MSCs) are an excellent potential source of cells for bone tissue engineering due to their excellent renewal ability and osteogenic differentiation capabilities. This study was designed to evaluate the bone formation properties of a demineralized cancellous bone scaffold seeded with MSCs, with or without periosteum, in a critical size bone defect model in rabbits. Me...