mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

background: abnormal pap smear consists of premalignant or malignant cervical lesions. many of premalignant cervical lesions will never progress to invasive malignancy, or even may regress over the time. thus, there is always a risk of overtreatment of patients with an abnormal pap smear. a long-term follow-up of these patients can reveal final events associated with each  subtype of abnormal p...

objective: breast cancer is one of the leading causes of death in women worldwide. conventional treatments use cytotoxic drugs which have high numbers of side effects. currently pharmacologists are searching for novel drugs with fewer side effects and maximum efficiency as breast cancer treatment. the aim of the current study is to clarify the cytotoxicity effect of the recombinant outer membra...

objective: the anti-cancer properties of curcumin, a poliphenol extract from the rhizome of curry, has been confirmed by many investigators. however, low levels of uptake, tissue distribution and rapid metabolism has limited its application as an anti-cancer drug. this study is aimed at increasing curcumin's water solubility due to a biodegradable, neutral and non-toxic micellar nano-carrier ca...

the two stable isotopes of hydrogen, protium (1h) and deuterium (2h) differ in their physicochemical nature. deuterium-depleted water (ddw) significantly inhibited the growth rate of different tumor cell lines in culture media and xenotransplanted mda-mb-231, mcf-7 human breast adenocarcinomas and pc-3 human prostate tumors in vivo. the apoptosis-triggering effect of ddw was demonstrated both i...

intraosseous squamous cell carcinoma is a rare type of squamous cell carcinoma that requires accurate and early diagnose which is important due to its invasive feature. this article presents a rare case report on intraosseous carcinoma in a 33-year-old patient. the case was a 33-year-old man who was referred to oral disease department of babol college of dentistry complaining of chin pain. in t...

background: bleomycin (blm) is an anti-cancer drug widely used in the treatment of cancer. blm causes several side effects related to dna and cellular damage. the aim of this study was investigated the effects of tea polyphenol epicatechin on anti-proliferative effects induced by bleomycin in human normal skin and human ovarian cancer cells.materials and methods: human ovarian cancer cell (skov...

cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. it has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior of variety of breast cancer cell lines. in spite of few investigations, there is a controversy in the literatures about the effects of adipocyte...

background and objective: neuroendocrine differentiation has not been proved to have effects in behavior of colorectal carcinomas. the aim of this study was immunohistochemical evaluation of neuroendocrine differentiation in colorectal cancer. patients and methods: in this cross-sectional study, 83 paraffin blocks from patients admitted in rasoul-e-akram hospital, tehran, iran, during 2003 to 2...