Remarkable progress has been achieved in understanding the mechanisms controlling sex determination, yet the cause for many Disorders of Sex Development (DSD) remains unknown. Of particular interest is a rare XX DSD subtype in which individuals are negative for SRY, the testis determining factor on the Y chromosome, yet develop testes or ovotestes, and both of these phenotypes occur in the same...

Mammary tumors are the most frequent neoplastic processes of the female dog and represent a problem of large impact in veterinary medicine. In this context, many efforts are being directed towards adopting criteria towards standardization of the diagnosis, understanding behavior and tumor evolution and evaluating prognostic and predictive factors such as: morphology, oncogenes expression and ge...

The heart and the kidneys act in tandem to regulate blood pressure, vascular tone, diueresis and to maintain intravascular volume homeostasis. Besides, the kidneys have a neuroendocrine function with interdependent physiological actions regulated by the renin-angiotensin-aldosterone system, sympathetic nervous system, and vasopressin and aterial natriuretic peptide. To investigate these complex...

The mainstay of comparative research for epilepsy has been rodent models of induced epilepsy. This rodent basic science is essential, but it does not always translate to similar results in people, likely because induced epilepsy is not always similar enough to naturally occurring epilepsy. A good large animal, intermediate model would be very helpful to potentially bridge this translational gap...

As we age, physiological or pathological tooth wear can alter our occlusion from canine-guided (or ‘canine-protected’) lateral excursion, to group function. Group function itself is not problematic, but the burden of excursion be damaging compromised teeth. It may desirable restore patient protect heavily restored A minimally invasive option canine ramp.

Spontaneous canine head and neck squamous cell carcinoma (HNSCC) represents an excellent model of human HNSCC but is greatly understudied. To better understand and utilize this valuable resource, we performed a pilot study that represents its first genome-wide characterization by investigating 12 canine HNSCC cases, of which 9 are oral, via high density array comparative genomic hybridization a...

The Kv4.3-encoded current (I:(Kv4.3)) has been identified as the major component of the voltage-dependent Ca(2+)-independent transient outward current (I:(to1)) in human and canine ventricular cells. Experimental evidence supports a correlation between I:(to1) density and prominence of the phase 1 notch; however, the role of I:(to1) in modulating action potential duration (APD) remains unclear....

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most worldwide frequent primary carcinomas resulting in the death of many cirrhotic patients. Unfortunately, the molecular mechanisms of this cancer are not well understood; therefore, we need a good model system to study HCC. The dog is recognized as a promising model for human medical research, namely compared with rodents. The objectiv...

this study was performed to determine the prevalence of canine parvovirus (cpv) in dogs referred to veterinary hospital of ahvaz, khouzestan province, iran. fecal samples were collected from 78 diarrheic dogs between 2005 and 2007. the dogs were divided into two age groups (< 6 months and > 6 months), four different breeds (terriers, germanshepherds, doberman pinschers and mixed) and another tw...

between july and august 2009, a total of two hundred crossbreed dogs in three contiguous littoralprovinces of guilan, mazandaran and golestan were sampled. circulating antigens and/or microfilariae ofdirofilaria immitis were found in 25.5% of dogs in the whole studied area. the highest infection rate wasfound in guilan (51.42%), followed by golestan and mazandaran provinces (15.38% and 7.69%, r...