Cannabis sativa preparations are the most commonly used illicit drugs worldwide. The present study aimed to investigate the effect of Cannabis sativa extract in the working memory version of the Morris water maze (MWM; Morris, 1984[43]) test and determine the effect of standard memory enhancing drugs. Cannabis sativa was given at doses of 5, 10 or 20 mg/kg (expressed as Δ(9)-tetrahydrocannabino...

The cannabis plant (Cannabis sativa L.) and products thereof (such as marijuana, hashish and hash oil) have a long history of use both as a medicinal agent and intoxicant. Over the last few years there have been an active debate regarding the medicinal aspects of cannabis. Currently cannabis products are classified as Schedule I drugs under the Drug Enforcement Administration (DEA) Controlled S...

Cannabinoids, flavonoids, and stilbenoids have been identified in the annual dioecious plant Cannabis sativa L. Of these, the cannabinoids are the best known group of this plant's natural products. Polyketide synthases (PKSs) are responsible for the biosynthesis of diverse secondary metabolites, including flavonoids and stilbenoids. Biosynthetically, the cannabinoids are polyketide substituted ...

Background As the point of physiology, memories form changes in the conducting message in the neural webs. These changes cause the formation of long-term potentiation. Δ9-THC is a psychotropic component of Cannabis sativa plant. Studies show this matter can bind Cannabinoid receptor in CA1 area of Hippocamp. Thus the aim of this study is to evaluate the effect of aqua extraction Cannabis sativa...

BACKGROUND AND OBJECTIVE: Epilepsy is one of the most common neurologic disorders that presents in a large number of drug-resistant patients. Given the presence of the anticonvulsant compounds in Cannabis and its use in traditional medicine, this study aims to evaluate the effect of Cannabis sativa extract on the treatment of seizures METHODS: In this experimental study, 40 Syrian male rats wer...

Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have unique medicinal properties. However, scientific research cannabis has been restricted by Single Convention on Narcotic Drugs 1961, an international treaty that prohibits production and supply narcotic drugs except under license. Legislation governing cultivation for research, even recreational purposes relax...

CONTEXT The use of the cannabis plant (Cannabis sativa L.) for the palliative treatment of cancer patients has been legalized in multiple jurisdictions including Israel. Yet, not much is currently known regarding the efficacy and patterns of use of cannabis in this setting. OBJECTIVES To analyze the indications for the administration of cannabis among adult Israeli cancer patients and evaluat...