To All(oc) involved: A palladium-catalyzed formal 5-endo-trig heteroannulation of enones generated in situ from amino acid derived β-keto nitriles has been realized (see scheme; Alloc=allyl carbamate). The reaction proceeds with allyl-group transfer from the carbamate protecting group to generate two new contiguous stereocenters, including one quaternary center, with high selectivity.

The methyl–amide complex [TaCp*(NBu)Me(NMe2)] (1a) was isolated by reaction of the chloro–methyl [TaCp*(NBu)MeCl] complex with LiNMe2. Reaction of the mono-amide compounds [TaCp*(N Bu)XY] (X=NMe2, Y=Me (1a); X=NHBu, Y=Me (1b), Cl (1c)) with CO2 gives the h-carbamate derivatives [TaCp*(NBu)(h-O2CX)Y] (X=NMe2, Y=Me (2a); X=NHBu, Y=Me (2b), Cl (2c)). A similar reaction with the di-amide complex [T...

Easy as 1,2,3: Reaction of methyl carbamate, triethyl orthoformate, and readily available alkenes provides a highly practical preparation of protected aminocyclopropanes. The reaction proceeds with preferential cis addition to alkenes, and cleavage of the methyl carbamate gives the free aminocyclopropanes as their HI salts.

A novel and convenient approach, the domino retro Diels-Alder/Diels-Alder reaction sequence for highly stereo- and regioselective synthesis of various bicyclo[2.2.2]octenone and bicyclo[2.2.2]octadienone derivatives is presented. Thus, the masked o-benzoquinones (MOBs) 2a-e generated by the pyrolysis of the respective dimers 3a-e participated in this novel synthetic strategy with a variety of o...

propoxure (ppx) is a well-known carbamate insecticide, which has been used for several decades in the world and iran in agriculture and public health programs. however, there is no clear investigation toward its immunotoxicity as yet. in this study, we examined the effects of subchronic i.p. exposure of ppx on humoral (pfc & ha) and cellular (dth) responses, and also monitored t-cell subtypes u...

During alcoholic fermentation, the yeasts responsible for process produce various metabolites, including urea. The reaction of urea with ethanol spontaneously generates ethyl carbamate in wine, a carcinogenic metabolite whose concentration needs to be regulated. Yeasts during arginine metabolic pathway. For this purpose, adaptive evolution has been used by using toxic analogue l-arginine, l-can...

Citation: Guerreiro TM, Ozawa KS, Lima EdO, Melo CFOR, de Oliveira DN, Triano SPdN and Catharino RR (2018) New Approach of QuEChERS and GC-MS Triple-Quadrupole for the Determination of Ethyl Carbamate Content in Brazilian cachaças. Front. Nutr. 5:21. doi: 10.3389/fnut.2018.00021 new approach of Quechers and gc-Ms Triple-Quadrupole for the Determination of ethyl carbamate content in Brazilian ca...

Malaria (vector: Anopheles gambiae) is a major infectious disease that kills about 1 million people each year. For the improvement of its treatment and vector control during the past decades, several issues such as high medicine cost, insecticide resistance, and lack of an effective vaccine have prevented adequate control of malaria. Additionally, the low selectivity of malaria vector insectici...

Selective meta-arylation of O-β-naphthyl carbamate has been accomplished using Pd(OAc)2 as a catalyst precursor and K2S2O8 with AgOAc as the oxidant. A range of aryl boronic acids could be introduced in moderate to good yields. Mechanistic investigation shows that the carbamate substituent has a unique effect and the reaction undergoes an ortho-carbometallation/meta-direct arylation process.

Screening of a library small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification potent benzoheterocyclic oxime carbamate hit series. This series was subjected medicinal chemistry progression underpinned by structure–activity relationship studies toward identifying compound for proof-of-concept and defining lead optimization strategy. Carbamate free frontrunner co...