There are several reports that adenosine and carbamazepine have pharmacodynamic interaction. I n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. Agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of R-phenylisopropyladenosine (R-PIA) substantially showed antinociceptive effects. Carbamazepine had antinociceptive acti...

The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of t...

The aim of this study was to compare the efficiency pharmaceuticals and personal care products’ (PPCP) removal in waterworks at Káraný (Czech Republic) Dresden-Hosterwitz (Germany). Both use similar technology drinking water production (combination bank filtration artificial recharge) have river quality (Jizera Elbe river). A comparison 2-year monitoring results shows high removing PPCP contain...

The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased disso...

The morphology of crystals has an appreciable impact role on the physicochemical properties of drugs. Drug properties such as flowability, dissolution, hardness and bioavailability may be affected by crystallinity behaviours of drugs. The objective of this study was to achieve an improved physicomechanical property of carbamazepine powder through recrystallization from aqueous solutions at diff...

OBJECTIVE Vitiligo is a rare side effect of carbamazepine whose exact mechanism is unknown. The aim of this report is to describe a single case of vitiligo induced by carbamazepine. METHODS The case was a patient with Bipolar I disorder whose medications were changed from valproate to carbamazepine and who developed vitiligo after a short while. We followed the case for about four years when ...

Bio-electro-Fenton is emerging as an alternative technology for the efficient and cost-effective removal of refractory micropollutants. Though promising, there are still several challenges that limit its wide application, including acidic operating conditions (pH at 2–3), addition supporting electrolytes (e.g., Na2SO4), issue iron sludge generation. To address these challenges, a novel hybrid p...

This work is part of the European research project LIFE15 ENV/ES/00598 whose objective was to develop an efficient and sustainable methodology eliminate Priority Substances (PS) Contaminants Emerging Concern (CEC), in Wastewater Treatment Plants (WWTP). The aim achieve reduce concentration PSs until their below quality limit established DIRECTIVE 2013/39/EU, reductions 99% initial for selected ...

We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures. Although asymptomatic, the biochemical abnormality improved after discontinuation of carbamazepine. Hyponatraemia developed after rechallenge with controlled release carbamazepine. The authors suggest that...

Calcium channel antagonists have been shown to have an anticonvulsant activity in a variety of seizure models and also to potentiate the anticonvulsant activity of other standard antiepileptic drugs like carbamazepine, phenytoin and valporoate. A pharmacokinetic interaction may be involved in such potentiation. This cross over single dose study was carried out to find out if there was a pharmac...