A panel of seven monoclonal antiepithelial antibodies of different specificities, including anticytokeratin, human milk fat globule membrane, C, and carcinoembryonic antigen (CEA) were used with the alkaline phosphatase-antialkaline phosphatase (APAAP) immunostaining technique to determine their value in the differentiation between benign and malignant mesothelial cells and lung carcinoma in hi...

This study aimed to assess independent effects of EBV and cigarette smoking on nasopharyngeal carcinoma, which have never been assessed in long-term follow-up studies. A cohort of 9,622 men was enrolled from 1984 to 1986. Blood samples collected at study entry were tested for antibodies against EBV antigens (anti-EBV) viral capsid antigen immunoglobulin A and DNase. The cigarette smoking habit ...

Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization technique. Polysaccharides and heavily-glycosylated proteins are very elusive target...

Abbreviations: BC: Bladder Cancer; MIBC: Muscle-Invasive BC; NMIBC: Nonmuscle-Invasive BC; BPH: Benign Prostatic Hyperplasia; CT: Computed Tomography; CEA: Carcinoembryonic Antigen; CA19-9: Carbohydrate-Antigen 19-9; HCC: Hepatocellular Carcinoma; TCC: Transitional Cell Carcinoma; UC: Urotherial Carcinoma; Hex: Hexose; Man: D-mannose; Gal: D-galactose; HexNAc: N-acetylhexsosamine; GlcNAc: N-ace...

Merkel cell polyomavirus (MCPyV) is an oncogenic virus etiologically related to carcinoma and has been found in association with non-melanoma skin cancer (NMSC), controversial results. Little known about the role or influence of MCPyV development these tumors its prevalence various populations. To assess MCPyV`s Large T Antigen DNA cases NMSC, nested-PCR immunohistochemistry (IHC) were performe...

We have previously shown that detection of autologous antibody activity to squamous cell carcinoma of the head and neck may be augmented by dissociation of immune complexes. Western blot analysis with autologous antibody has identified a 60 kDa squamous cell carcinoma of the head and neck-associated antigen in spent media and immune complex-dissociated serum ultrafiltrate not recognized by norm...

Hepatitis B e antigen serum persistence in an individual chronically infected with the Hepatitis B virus may be associated with a greatly increased risk of developing cirrhosis and hepatocellular carcinoma. This article presents an overview of the Hepatitis B e antigen and discusses the findings of a recent study evaluating its associated risk of hepatocellular carcinoma. A gross photographic i...

Background Despite a high prevalence of endometriosis, there still exist many challenges in diagnosing the disease. This study aims to evaluate non-invasive and practical diagnostic methods by measuring serum and peritoneal fluid CA 125 levels in patients with endometriosis. A secondary aim is to determine the correlation between these markers with the stage of disease as well as the relationsh...

Breast carcinoma is one of the most frequently occurring cancers among women with million cases. cancer primary cause death in around world. It major concerns public health due to its high occurrence and growing tendency. This complex functional structure develops from a highly modified apocrine sweat gland female, but remains rudimentary male. embryological into two lines along milk extending ...