While the mortality rate associated with sepsis in children has fallen over the years, it still remains unacceptably high. The development of both acute cardiac dysfunction and acute kidney injury during severe sepsis is categorized as type 5 cardiorenal syndrome (CRS) and is poorly understood in infants. To address this lack of understanding and the need for an appropriate animal model in whic...

STUDY OBJECTIVES Cardiac surgery with cardiopulmonary bypass (CPB) is associated with major inflammatory triggers that cause marked activation of the microcirculation. This inflammatory response is associated with significant organ dysfunction. How this response causes organ dysfunction is not well understood; consequently, few interventions exist to prevent or treat it. In other acute inflamma...

The mechanisms contributing to multiorgan dysfunction during cardiogenic shock are poorly understood. Our goal was to characterize the microcirculatory and mitochondrial responses following ≥ 10 hours of severe left ventricular failure and cardiogenic shock. We employed a closed-chest porcine model of cardiogenic shock induced by left coronary microembolization (n = 12) and a time-matched contr...

Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in...

In this paper, we adapt a previously developed poromechanical formulation to model the perfusion of myocardium during cardiac cycle. First, complete is derived in 3D. Then, perform dimensional reduction under assumption spherical symmetry and propose numerical algorithm that enables us simulations myocardial throughout These illustrate use proposed represent various physiological pathological s...

Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in...

Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that maintaining systemic blood pressure is associated with inadequate perfusion of the microcirculation in sepsis. Microcirculatory perfusion is regulated by an intricate interplay of many neuroendocrine and paracrine pathways, which makes blood flow though this microvascular network a heterogeneous process. Owing to ...

abstract         background and objective: scientific evidence reveals that the density of skeletal muscle microcirculations decreases in the patients with chronic heart failure. therefore, this study aimed to determine the impact of submaximal aerobic exercise training on restoration of fast/slow-twitch muscle fibers microcirculation in rats with myocardial infarction.          methods: in thi...

Introduction Microcirculatory alterations have been correlated with poorer outcomes in different populations of critically ill patients. A controlled increase in the local skin temperature (thermal challenge) induces vasodilation, which may represent a measure of microcirculation recruitability and can be easily evaluated non-invasively using skin laser Doppler (SLD) (1). We previously demonstr...

The paper presents the results of a comprehensive assessment central hemodynamic and microcirculation indices in skin upper lower limbs 6–7-year-old children. 14 girls 7 boys were examined using laser Doppler flowmetry methods (the LASMA-PF device, allowing simultaneous recording by four sensors) analysis heart rate variability ("Varicard"). parameters characterizing determined signs appearing ...