BACKGROUND AND PURPOSE Carotid intima-media thickness (IMT) is a surrogate marker of subclinical atherosclerosis and a strong predictor of stroke and myocardial infarction. The object of this study was to determine the association between carotid IMT and 702 single nucleotide polymorphisms in 145 genes. METHODS B-mode carotid ultrasound was performed among 408 Hispanics from the Northern Manh...

Because carotid angiography has been shown to have limitations in the detection of intimal disease at the bifurcation, a new method of examination of the extracranial carotid artery has been developed using thin-section dynamic computed tomographic (CT) scanning. Carotid atheroma and thrombi can be imaged directly on these sections. The intimal lesions are uniformly hypodense with respect to th...

Because carotid angiography has been shown to have limitations in the detection of intimal disease at the bifurcation, a new method of examination of the extracranial carotid artery has been developed using thin-section dynamic computed tomographic (CT) scanning. Carotid atheroma and thrombi can be imaged directly on these sections. The intimal lesions are uniformly hypodense with respect to th...

Computational fluid dynamics (CFD) models of the carotid artery are constructed from contrast-enhanced magnetic resonance angiography (MRA) using a deformable model and a surface-merging algorithm. Physiologic flow conditions are obtained from cine phase-contrast MRA at two slice locations below and above the carotid bifurcation. The methodology was tested on image data from a rigid flow-throug...

The persistent primitive hypoglossal artery (PPHA) is the second most common persistent carotid-vertebrobasilar anastomosis, with an incidence of 0.027-0.26%. PPHAs change the hemodynamics of the carotid and vertebrobasilar system and may be associated with intracranial vascular anomalies, but basilar bifurcation aneurysms were rarely reported. We describe the first case of a PPHA as the sole s...

We prospectively studied the results of carotid angiography in 45 patients with transient or nondisabling neurologic deficits caused by lacunar infarction in the internal capsule or corona radiata and demonstrated by computed tomography. An ipsilateral stenosis at the bifurcation of the internal carotid artery was found in 14 patients (31%, 95% confidence limits 18-47%), seven of whom also had ...

In this study we determined mean-average wall shear stress values in the common carotid artery and assessed if there is a difference in mean-average WSS between: 1) patients with bilateral carotid bifurcation disease and 2) similar-aged volunteers with no evidence of disease. Sixteen patients with bilateral disease of the carotid bifurcation, and 8 volunteers were included in the study. Magneti...

We prospectively studied the results of carotid angiography in 45 patients with transient or nondisabling neurologic deficits caused by lacunar infarction in the internal capsule or corona radiata and demonstrated by computed tomography. An ipsilateral stenosis at the bifurcation of the internal carotid artery was found in 14 patients (31%, 95% confidence limits 18-47%), seven of whom also had ...

Hemodynamic mechanisms for the initiation and progression of carotid bifurcation atherosclerotic occlusive disease have been extensively researched during the past few decades. Attention has focused on the carotid bulb, or sinus, where most atherosclerotic plaques are found. Herein, the authors review the seminal works that have led to an understanding of not only complex local hemodynamics but...

Carotid artery bifurcation (CB) is the preferred site for development of atherosclerosis (AS) in extracranial cerebral arteries; internal carotid artery stenosis is the most common cause of ischemic stroke. The frequent atherosclerotic disease of CB may best be explained by the hemodynamic influence of complex blood flow that results from the unique geometry of the bifurcation. Few papers analy...