Transdermal therapeutic system scopolamine (TTS-S) is effective in preventing motion sickness for 72 h. However, by this route a prophylactic effect is obtained 6 to 8 h postapplication. By the oral route, scopolamine is effective within 0.5 h for a period of 6 h. To achieve safe as well as effective protection against seasickness during the first hours of a voyage until the TTS-S patch takes e...

This paper presents methods for automatic speech signal segmentation using neural network. Speech signal segmentation is carried out to form syllables. Syllable is a common unit for concatenative TTS systems. Concatenative TTS being using speech segments of recorded speech is natural as compare to Formant or Articulatory TTS systems. This TTS stores small segments of speech and join them togeth...

I read with great interest the report by Murugiah et al. (1) and the accompanying editorial by Sharkey (2), published in JACC: Heart Failure, about the prevalence of Takotsubo syndrome (TTS) and some relevant particulars of patients in the United States, derived from the 2007 to 2012 Centers for Medicare & Medicaid Services dataset. The authors and the editorialist (1,2) refer to the important ...

From the Hypertension Section, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich. This study was assisted by U. S. Public Health Service Grant 5MOl-FR-42 to the Clinical Research Unit, University of Michigan Medical Center, which enabled hospitalization of patients included in the study. Manuscript received December 14, 1970, accepted February 12, 1970. Add...

Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of these central alpha-adrenergic receptors has been shown to activate an ...

Într-un sistem de sinteză a vorbirii pornind de la text (TTS), prezenţa etajului de prelucrare a limbajului natural este esenţială dacă se doreşte obţinerea unei vorbiri sintetizate cât mai naturală, pornind de la un text oarecare de intrare. În lucrarea de faţă abordăm două probleme importante pentru un sistem TTS în limba română, din punct de vedere al prelucrării limbajului: despărţirea auto...

OBJECTIVE To deliver 2,3,5,6-tetramethylpyrazine (TMP) in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. METHODS The pseudo-ternary phase diagram for microemulsion regions was constructed using isopropyl myristate as oil phase, Labrasol(®) as surfactant, and Plurol(®) Oleique CC 497 as cosurfactant. A...

748 March 2013 U ncuffed tracheal tubes (TTs) have been the standard for tracheal intubation in infants and children for decades until the recent introduction of the Microcuff (Kimberley-clark, Roswell, GA) cuffed TT. evidence suggests that the incidence of perioperative airway events after use of these new TTs is small,1,2 although the evidence for their safe use in neonates and young infants ...

In this paper a low footprint multilingual text-to-speech (MLTTS) framework is presented. The system is a part of a speaker independent name dialing system that has been introduced in Nokia Series 60 mobile phones. In the ML-TTS systems that are based on the Klatt88 engine there usually exist sets of language specific rules that are used to modify the speech synthesis parameters. Usually, the s...