Carbon tetra chloride (CCl4) induced acute hepatotoxicity causes severe damage to hepatocytes and affects the liver functions which resemble various liver ailments like hepatitis, jaundice, cancer etc. Using 12-different fruits, formulation F1 and F2 were prepared. Hepatoprotective potential of the formulations was assessed using HepG2 cell (in vitro) and rat model (in vivo). Biochemical parame...

in india, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. no systemic study has been done on protective effect of cucumis trigonus roxb. (cucurbitaceae) to treat hepatic diseases. protective action of c. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

BACKGROUND Liver diseases are major global health problems. Ginseng extract has antioxidant, immune-modulatory and anti-inflammatory activities. This study investigated the effect of ginseng extract on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. METHODS Male Wistar rats were divided into four groups: control group, ginseng group, CCl4 group and CCl4 + ginseng group. Liver inju...

Previous studies have demonstrated that alpha-tocopheryl hemisuccinate (TS) protects hepatocyte suspensions from chemical-induced toxicity. It has been suggested that TS cytoprotection is related to unique properties of the TS molecule or is dependent on the cellular release and activity of unesterified alpha-tocopherol (T). To test the unique cytoprotective nature of TS in vivo, the protective...

The present study was conducted to evaluate the effect of alcoholic extract A.webbiana leaves Lindl on liver and kidney. Wistar rats were divided into three groups (n=3) for hepatotoxicity and nephrotoxicity. Alcoholic leaves extract of A.webbiana was evaluated for protective effects against CCl4 induced hepatotoxicity and cisplatin induced nephrotoxicity. Hepatotoxicity studied by comparing pa...

fruits, leaves and tuberous roots of momordicia diocia are used in india as a folk remedy for treatment of a wide range of disorders. the objective of this study was to evaluate the hepatprotective activity of the fruits of momordicia diocia by preparing different extracts and the resultant extract were screened for the hepatprotective activity. the ethyl acetate and ethanolic extracts of momor...

BACKGROUND Nowadays attention to use herbs such as cornelian cherry (Cornus mas) is increasing, which contains high levels of antioxidants and anthocyanins. Cornus mas fruits have been used for gastrointestinal and excretory disorders for many years in traditional medicine, also may improve liver and kidney functions, and have protective effects such as anti-allergic, antidiabetic, antibacteria...

The effects of aqueous leaves extract of the Gardenia ternifolia plant (ALEGTP) was investigated against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Thirty albino rats were used for the experiment and grouped into six (n=5); group 1 and 2 were normal and control respectively. Group 3 was pretreated with silymarin while group 4, 5 and 6 were pretreated with 100, 200 and 400 mg/kg...

The methanol extract of Bauhinia racemosa Lam. (Caesalpiniaceae) stem bark was investigated for the antioxidant and hepatoprotective effects in Wistar albino rats. Different groups of animals were administered with paracetamol (500 mg/kg, (p.o.) once in a day for 7 days) and carbon tetrachloride (CCl4) (30 % CCl4, 1 ml/kg b.wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The methanol e...

The present study aimed to revealing and identifying some of phytochemical compounds, bioactive fatty acids antioxidants for powder leaves seeds Moringa oleifera that cultivated in Iraq which have been many identified by using modern techniques such as gas chromatography mass spectrometry (GC-MS) technique. And then test the preventive Therapy effects against hepatotoxicity induced carbon tetra...