Malignant gliomas are the most common primary intrinsic brain tumors and are highly lethal. The widespread migration and invasion of neoplastic cells from the initial site of tumor formation into the surrounding brain render these lesions refractory to definitive surgical treatment. Stathmin, a microtubule-destabilizing protein that mediates cell cycle progression, can also regulate directed ce...

The authors administered procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, lomustine), and vincristine (PCV) to 86 patients with recurrent glioblastoma. There were three partial responses, but no complete responses. Median progression-free survival was 17.1 weeks and progression-free survival at 6 months was 38.4%. World Health Organization grade III/IV hematologic toxicity was ...

Shaoying Gong, Xiaoyun Chai, Ting Duan, Liu Zhong, Yongqing Jiao Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China Center for Mental Health Education, Hubei University of Automotive Technology, Shiyan, Ch...

Abbreviations: AG, anaplastic glioma; BCNU, 1,3-bis( CCNU, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; G ratio; O-meG, O-methylguanine; MGMT, O-methylgu MSP,methylation-specific PCR; PFS, progression-free surv temozolomide ⁎ Corresponding author at: Department of Neurol Washington, Box 356470, 1959 NE Pacific Street, Se Fax: +1 206 543 8315. E-mail address: [email protected] (J.R. Sil...

Specific interventions included in the review Various adjuvant treatments including chemotherapy, radiotherapy alone or in combination with chemotherapy, and chemoimmunotherapy. The drugs studied were: thiotepa, 5-fluorodeoxyuridine, mitomycin C, 5-fluorouracil, adriamycin, vincristine, cyclophosphamide, methyl CCNU, vinblastine, 1,3-bis(2 chlorethyl)-1-nitrosourea, tegafur, cytosine arabinosid...

- astrocytomas, including glioblastoma multiforme (gbm), arc the most common brain tumors. post-operative radiotherapy plays an important rote in their treatment. records of all patients with a pathologic diagnosis of astrocytoma referred for radiotherapy from 1987-1992 were reviewed and prognostic factors with regard to recurrences were analyzed. during the study period, 162 astrocytoma patien...

Abstract INTRODUCTION Multiply recurrent glioblastoma suffers from poor response rates to treatment, and limited durability. We describe a case of an impressive third-line CCNU/TMZ. BACKGROUND Headaches brought 76-year-old man medical attention. MRI identified enhancing right temporal mass -- path following resection demonstrated (IDH-wildtype, MGMT-methylated, TERT mutant; PTEN Y68H, CDKN2A/B ...