Long-lived antibody-secreting plasma cells are essential to establish humoral memory against pathogens. While a regulatory transcription factor network has been established in cell differentiation, the role of miRNAs remains enigmatic. We have recently identified miR-148a as most abundant miRNA primary mouse and human cells. To determine whether this signature controls vivo development B into l...

Macrophages are dynamic cells integrating signals from their microenvironment to develop specific functional responses. Although, microarray-based transcriptional profiling has established transcriptional reprogramming as an important mechanism for signal integration and cell function of macrophages, current knowledge on transcriptional regulation of human macrophages is far from complete. To d...