Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptor...

Abstract Regulatory T cells (Tregs) exert immunosuppressive functions and hamper anti-tumor immune responses in the tumor microenvironment. Understanding heterogeneity of intratumoral Tregs, how it changes with progression, will provide clues regarding novel target molecules Treg-directed therapies. Here we characterized phenotypes suppressive function Tregs from tissues 42 patients renal cell ...