Integrin-mediated adhesion regulates cellular responses to changes in the mechanical and biochemical properties of extracellular matrix. Cell–matrix caveolar endocytosis, dependent on caveolin 1 (Cav1) Tyr14 phosphorylation (pY14Cav1), control anchorage-dependent signaling. We find that cell–matrix pY14Cav1 levels mouse fibroblasts. Biochemical fractionation reveals endogenous be present caveol...

Background: The immune-mediated responses in vascular cells may include the increased expression of endothelial adhesion molecules, leukocyte rolling and infiltration, cellular lipid dysregulation and vascular smooth muscle cells (VSMCs) differentiation. Investigating the cellular and molecular events involved in the rolling process is useful for treatment or prevention of the vessel stenosis es...

Cell Adhesion In article number 2110340, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang, and co-workers report template-mediated in situ tuning of nanoligand size spacing. They demonstrate that submolecular ligand spacing magnetic anchoring facilitate adhesion-structure assembly-mediated pro-healing polarization host macrophages. Increasing the significantly suppresses macrophage adhesion wh...

kcnk2 was previously shown to regulate immune-cell trafficking into the central nervous system (cns). kcnk2-/- mice demonstrated a more severe disease course in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, due to an increased immune-cell migration into the cns. an upregulation of the cellular adhesion molecules icam1 and vcam1 on brain endothelial cells in k...

The interaction of Herpes Simplex Virus type 1 (HSV-1) with human fetal foreskin fibroblast (HFFF) cell was studied using a recent isolate of HSV-1 which was propagated in Hep-2 cells. HFFF cells were challenged with HSV-1 with a multiplicity of infection (MOI) of 1 virus/cell for 24 hours. Flow cytometric analysis demonstrated that HSV-1 challenged HFFF cells expressed increased levels of α2β1...

Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders. Biomaterial scaffolds can improve cell differentiation and are widely used in translational medicine and tissue engineering. The aim...