human t-ceil lymphotropic virus, type 1 (htl v-i) is considered to be the causative agent of adult t-cell lymphoma/leukemia and spastic paralysis, and seems to be common in khorasan province. 300 blood samples from mashhadi and 180 from gonbadi blood donors were obtained (all samples from healthy subjects). serological screening was done by passive particje- agglutination test and confirmed by ...

After the addition of human T-cell lymphotropic virus type I (HTLV-I)-infected lymphocytes to enterocyte monolayers, the lymphocytes adhered via microvilli from both cell types and shed virus onto the enterocyte surface. Virus fused with the epithelial membrane and infected these cells as confirmed by electron microscopic immunocytochemistry, in situ hybridization, and amplification by polymera...

Adult T-cell leukemia-lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landsc...

Abstract Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive malignancy that arises in proportion of individuals who are long-term carriers human T-lymphotropic virus type 1. The median survival subtypes 8 to 10 months; with chemotherapy-based approaches, overall has remained largely unchanged the ?35 years since ATL was first described. Through use 4 representative case studies, we hig...

The study of animal retroviruses has yielded fundamental insight into molecular pathways of carcinogenesis, while human retroviruses predispose infected persons to develop malignant disease. Human T-cell lymphotropic virus type I (HTLV-I) causes adult Tcell leukaemia. Human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2) indirectly cause lymphoma, Kaposi’s sarcoma and cervical carcinoma by ...

Human T-cell lymphotropic virus type I has been associated with adult T-cell leukemia and lymphoma, neurological disease (tropical spastic paraparesis or HTLV-I associated myelopathy) and, more recently, uveitis. This virus is highly endemic in some regions of the world, especially in southwest Japan, Caribbean islands, South America and parts of Central A frica1. The presence of HTLV-I/II in B...

Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.

B-cell infection by hepatitis C virus (HCV) has been a controversial topic. To examine whether HCV has a genetically determined lymphotropism through a co-receptor specific for the infection by lymphotropic HCV, we established an infectious clone and chimeric virus of hepatotropic and lymphotropic HCV strains derived from an HCV-positive B-cell lymphoma. The viral envelope and 5'-UTR sequences ...

We compared an antigen capture assay (Abbott Laboratories, North Chicago, Ill.) with a reverse transcriptase assay to identify and quantify human immunodeficiency virus (HIV) in culture. In direct comparisons of serial dilutions of lymphadenopathy-associated virus type 1, the antigen assay was 100-fold more sensitive than the reverse transcriptase assay in detecting the virus. The antigen assay...

We reported two cases of patients with coinfection by human immunodeficiency virus (HIV) type 1 and human T-cell lymphotropic virus (HTLV) type I who developed opportunistic infections despite of relatively high CD4+ cells count. These cases showed clinical evidence to consider an earlier antiretroviral treatment for coinfected patientes regardless CD4+ cells counts.