Outer hair cell electromotility is crucial for the amplification, sharp frequency selectivity, and nonlinearities of the mammalian cochlea. Current modeling efforts based on morphological, physiological, and biophysical observations reveal transmembrane potential gradients and membrane tension as key independent variables controlling the passive and active mechanics of the cell. The cell's mech...

the aim of the present paper is to sbo» that anti-realism in science, 1vhich has a1;guab/y become more fashionable in recentyears, contrary to tuha: its proponents assert, cannot make use of quantum mechanics and its impressiue achievements as a frump card in justifying its claims. i will argue that scientific anti-realism far from providing scientific communiry with a progressive methodologica...

Studies on the deformation behaviours of cellular entities, such as coated microbubbles and liposomes subject to a cavitation flow, become increasingly important for the advancement of ultrasonic imaging and drug delivery. Numerical simulations for bubble dynamics of ultrasound contrast agents based on the boundary integral method are presented in this work. The effects of the encapsulating she...

Spheroids are widely used in vitro 3D multicellular model systems that mimic complex physiological microenvironments of tissues. As different cell types vary deformability and adhesion, the choice (heterogeneous) composition will define overall spheroid mechanics, including their viscoelasticity effective surface tension. These mechanical parameters directly influence sorting possibly invasion ...

Technical advances are providing new insights into the mechanical properties of cells. Now, by combining genetic and biochemical studies with high-resolution mechanical measurements from atomic force microscopy, the biochemical bases of mechanical processes such as cytokinesis should be discernible.

All models are wrong, but some are useful. This famous saying mirrors the situation in cell mechanics as well. It looks like no particular model of the cell deformability can be unconditionally preferred over others and different models reveal different aspects of the mechanical behavior of living cells. The purpose of the present work is to discuss the so-called tensegrity models of the cell c...