Pseudohyperkalemia occurs occasionally in leukemic patients with excessively elevated white blood cells. Early diagnosis of pseudohyperkalemia is crucial for proper treatment. Increased cell fragility coupled mechanical trauma may be the causal mechanism. We describe two cases caused by disruption cells due to pneumatic tube transport specimens. In case when extraordinarily elevated, specimen s...

In Dictyostelium, the RtoA protein links both initial cell-type choice and physiological state to cell-cycle phase. rtoA- cells (containing a disruption of the rtoA gene) generally do not develop past the mound stage, and have an abnormal ratio of prestalk and prespore cells. RtoA is also involved in fusion of endocytic/exocytic vesicles. Cells lacking RtoA, although having a normal endocytosis...

Abstract Differentiation of CD8 T cells into a terminally exhausted state is major hurdle limiting efficacy both immune checkpoint blockade and adoptive cellular immunotherapy approaches. Prior studies describing disruption the epigenetic regulators DNMT3A TET2 in have revealed critical role DNA methylation repressing proliferative capacity effector potential during exhaustion. Disruption these...

Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...

in this study, the effect of irrigation regimes and plant nutrition were evaluated as split plot arrangment based on randomized complete block design with three replications in 2010. treatments consisted of irrigation regimes at three levels: well-irrigation, irrigation disruption at vegetative growth stage, and irrigation disruption at reproductive growth stage as main plots and combination of...

Background: In apoptosis is physiological cell death which eliminates injured and old cells. Any disruption in apoptosis, leads to disease. Resveratrol is a natural polyphenol with estrogen-like, antioxidant and antiinflammatory properties; also it showed cell prolifratory and inhibitory effect. The aim of present study was to determine resveratrol effect on apoptosis of human endometrial epith...

We previously reported that natural killer (NK)-sensitive target cells, K562, kill interleukin-2-stimulated (lymphokine-activated killer [LAK]) but not unstimulated NK cells. We have now investigated the molecular basis of this phenomenon. Soluble monoclonal antibody (MoAb) to CD18 inhibited 75% of K562-induced DNA fragmentation and membrane disruption, whereas blocking MoAb to Fas partially in...

BACKGROUND Signs of preceding episodes of plaque rupture and smooth muscle cell (SMC)-mediated healing are common in atherosclerotic plaques, but the source of the healing SMCs is unknown. Recent studies suggest that activated platelets adhering to sites of injury recruit neointimal SMCs from circulating bone marrow-derived progenitor cells. Here, we analyzed the contribution of this mechanism ...

In the present work, bakers yeast catalyzed efficient synthesis of 2-amino-2-chromenes in methanol is presented. Here ultrasonication has dual role i.e. as a source energy for reaction and tool disruption cells. The cyclocondensation been essentially carried under neutral conditions, thus reducing possibility unwanted side reactions.