the possibility of chemical modification of peptides and proteins under the condition of proteolytic digestions and fabms analysis was investigated. the results ;indicate that among the amino acid constituents of peptides and proteins: serinefcysteine, and cystine are the most sensitive residues which undergo chemical modificadons under the exprimenta1 conditions. the chemical modification of t...

the characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. in this report we characterise a leukemic model, d5a1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. cells induced with 4 mm hexamethylene bisacetamide (hmba) caused signs...

Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs) was discovered over a decade ago, a huge number of cellular proteins have been found to be reversibly modified, resulting in alteration of differential cellular pathways. Although the molecular consequences of SUMO attachment are difficult to predict, the underlying principle of SUMOylation is altering i...

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We exa...

dear editor: we would like to present a modified method for cerebrospinal fluid collection in anesthetized rat. this method is easy and applicable in many laboratories interested by research on cellular and molecular effects of csf on different pathways.

Electrospinning is a simple and versatile technique that relies on the electrostatic repulsion between surface charges to continuously draw nanofibers from a viscoelastic fluid. Electrospinning can generate nanofibers with a number of secondary structures. Surface and/or interior of nanofibers can be functionalized with molecular species or nanoparticles during or after an electrospinning proce...

Abscisic acid (ABA) is recognized as the key hormonal regulator of plant stress physiology. This phytohormone also involved in growth and development under normal conditions. Over last 50 years components ABA machinery have been well characterized, from synthesis to molecular perception signaling; knowledge about fine regulation these starting increase. In this article, we review a particular t...

background: alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. the biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interaction...

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We exa...

The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...