micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

BACKGROUND Coronary collateral arteries function as natural bypasses in the event of coronary obstruction. The degree of collateral network development significantly impacts the outcome of patients after an acute myocardial infarction (AMI). MicroRNAs (miRNAs, miRs) have arisen as biomarkers to identify heterogeneous patients, as well as new therapeutic targets in cardiovascular disease. We sou...

A meth~ fi~r the hmalization, characterizadcm and ctnnputatitm of the stationary ptfints of a cxmtinutatsly differentiable real-valued fimction tff n variables is presented. It is based on the annbinatoriai topohgy concept of the degree of a mapping associated with an oriented polyhednm. The method consists of two principal steps: (i) Iocalizati, m (and am~putation if required) of a ~ationary p...

Kernel methods have been very popular in the machine learning literature in the last ten years, mainly in the context of Tikhonov regularization algorithms. In this paper we study a coherent Bayesian kernel model based on an integral operator defined as the convolution of a kernel with a signed measure. Priors on the random signed measures correspond to prior distributions on the functions mapp...

Research in proteomics has exploded in recent years with advances in mass spectrometry capabilities that have led to the characterization of numerous proteomes, including those from viruses, bacteria, and yeast. In comparison, analysis of the human proteome lags behind, partially due to the sheer number of proteins which must be studied, but also the complexity of networks and interactions thes...

We derive analytic expressions for infinite products of random 2 × 2 matrices. The determinant of the target matrix is log-normally distributed, whereas the remainder is a surprisingly complicated function of a parameter characterizing the norm of the matrix and a parameter characterizing its skewness. The distribution may have importance as an uncommitted prior in statistical image analysis.

The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have been investigated as solvents in the range temperatures from a 298.15 to 348.15 K. Owing to the absence of cis,cis-muconic acid solubility...