All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough chemo- and radiotherapy are still a gold standard in cancer treatment, the identification of non-toxic compounds that enhance their selectivity, would allow for lowering their doses, reduce side effects and risk of second cance...

INTRODUCTION Adenoid cystic carcinoma is a malignant epithelial neoplasm derived from the salivary glands. Primary adenoid cystic carcinoma of the cervix is extremely rare, accounting for less than 1% of all cervical carcinomas. In this paper we report a case of primary adenoid cystic carcinoma and a review of the related literature. CASE PRESENTATION A 68 year-old woman was admitted with sig...

AIMS To investigate the immunohistochemical expression of p53 and bcl-2 proteins in squamous cell carcinoma (SCC) of the oesophagus and to assess whether expression of these oncoproteins can be used to stratify patients into groups with a favourable or unfavourable response to preoperative chemo/radiotherapy. METHODS The initial diagnostic biopsy and the corresponding resected samples were ob...

Metastatic seeding along image-guided brain biopsy tracts is an uncommon phenomenon. We report a case of meningeal glioblastoma (GBM) metastasis at the site of a previous image-guided biopsy site, which developed 14 months after completing concurrent chemo-radiotherapy. This is the first reported case of successful treatment of an intracranial GBM metastasis with resection followed by radiother...

The aim of this study was to evaluate the effectiveness and tolerability of definitive chemo-radiation or radiotherapy alone in patients with esophageal cancer. We retrospectively analyzed the medical records of n = 238 patients with squamous cell carcinoma or adenocarcinoma of the esophagus treated with definitive radiotherapy with or without concomitant chemotherapy at our institution between...

Historically locally advanced cervical cancer was treated with teletherapy and a boost with brachytherapy. But in 1999 the treatment changed favorably, thus establishing the current management based on concurrent chemo-radiotherapy, thanks to the publication of some studies [1,2] that showed survival advantage of this disease with the addition of platinum-based chemotherapy and radiotherapy (Fi...

OBJECTIVE Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing multimodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centres. METHODS AND MATERIALS Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative che...

Background. Myelosuppression is one of the major side effects of chemo- and radiotherapy in cancer patients and there are no effective interventions to prevent it currently. Chinese herbal medicine (CHM) may be helpful due to its multidrug targets. Objectives. This study was designed to evaluate effectiveness of CHM on preventing patients from experiencing myelosuppression by chemo- or radiothe...

Background: The rectum is the lower part of colon. Its cancer third most common worldwide. Aim: To determine frequency and severity acute perineal skin reactions in rectal patients at completion preoperative pelvic radiotherapy. Study Design: Descriptive case series. Methodology: conducted Department Clinical Oncology, Shaukat Khanum Memorial Cancer Hospital Multan. Patients (n=96) were enrolle...

Purpose To explore whether polymorphisms in base excision repair (BER) pathway genes are predictors of (chemo)radiotherapy outcome in patients with nasopharyngeal carcinoma (NPC). Methods We genotyped five potentially functional single nucleotide polymorphisms (SNPs) of three genes in the BER pathway in 174 NPC patients who were treated with (chemo)radiotherapy. Sequenom MassArray was used fo...