نتایج جستجو برای: chemoenzymatic
تعداد نتایج: 829 فیلتر نتایج به سال:
Abstract Prunetin (4′,5-dihydroxy-7-methoxyisoflavone) was semisynthesized in 8 steps from readily available naringenin 26% total yield. The key reaction chemoenzymatic sequential deacetylation to 6′-acetoxy-2′,4″-dihydroxy-4′-methoxychalcone, the situ-formed precursor for thallium(III) nitrate-mediated oxidative rearrangement.
Terpenoids represent a valuable class of bioactive fine chemicals and are therefore attractive targets for synthetic modification; modulation of their natural properties may lead to new medicinal and agrochemical compounds with improved properties. However, the complexity of the hydrocarbon skeletons and the often significant chemical instability of many terpenoids can present a formidable chal...
Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the 3-hydroxypiperidine skeleton. The introduction of the quinazolone-containing side chain in both strategies was based on an N-acyliminium ion-mediated coupling reaction.
Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent k...
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