Chemotherapy is widely used for the treatment of various cancers. DNA-damaging and anti-mitotic drugs are the two types of chemotherapeutic drugs. DNAdamaging drugs such as doxorubicin, etoposide, and cisplatin, are involved directly in DNA double strand breaks. Anti-mitotic drugs inhibit mitosis by targeting microtubules and preventing their polymerization or depolymerization. Paclitaxel, doce...

Suppression of protein kinase A regulatory subunit 1 alpha (PRKAR1A) has been proven to inhibit cholangiocarcinoma (CCA) cell growth and enhance apoptosis. In the present study, we aimed to determine synergistic and/or additive effects of chemotherapeutic agents, including protein kinase inhibitors (i.e. sorafenib, sunitinib, gefitinib, Met inhibitor) and conventional chemotherapeutic drugs (i....

The efficacy of chemotherapeutic drug in cancer treatment is often hampered by drug resistance of tumor cells, which is usually caused by abnormal gene expression. RNA interference mediated by siRNA and miRNA can selectively knock down the carcinogenic genes by targeting specific mRNAs. Therefore, combining chemotherapeutic drugs with gene agents could be a promising strategy for cancer therapy...

Abstract Background The skin is both a target and potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated superparamagnetic iron oxide nanoparticles to facilitate transdermal anticancer agents. Results Chemotherapeutic cancer drugs were applied with or without hairless mice, their ability penetrate was assessed usi...

Pediatric cancer treatment includes several chemotherapeutic drugs in combination with adequate supportive management. Symptom distress among pediatric patients on chemotherapy interferes compliance. Poorly managed leads to the decline of child’s ability physically and mentally deteriorates quality life. This paper shows effect induced symptom distress, early diagnosis management improvement li...