Among the methods for asymmetric synthesis, enantioselective catalysis is one of the representatives to produce enantio-enriched molecules in an efficient and practical manner. Catalytic enantioselective nucleophilic addition to pro-chiral electrophiles such as aldehydes, ketones, imines, and electron deficient double bonds is one of the most extensively investigated reactions, and substantial ...

A ny object that cannot be superimposed upon its mirror image is said to be chiral, and the two mirror image forms are called enantiomers. A person’s left and right hands are one familiar macroscopic example of chiral objects. Chirality is of immense interest in chemistry, because many organic molecules are chiral. Any atom in a molecule that is tetrahedrally bonded to four different functional...

The synthesis of non-racemic 5-membered cyclic carbonates from abundant alcohols is reported. Conversion the alcohol into an azanyl carbonate followed by a chiral-at-ruthenium catalyzed cyclization to provide chiral in yields up 95% and with 99% ee. This new synthetic method proposed proceed through nitrene-mediated intramolecular C(sp 3 )−H oxygenation which includes very unusual 1,7-hydrogen ...

We report catalytic, enantioselective intramolecular hydroacylation of N-vinylindole-2-carboxaldehydes. These hydroacylation reactions occur in the presence of a readily accessible rhodium catalyst and form chiral, non-racemic 2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ones in high yields with excellent enantioselectivities.

The development and application of chiral, non-racemic Re(V)-oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer-Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of im...

chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. derivatives of spirooxindole find very wide biological applications as anti micr...

A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5.

Both chiral and racemic phosphatidylethanolamines are known to crystallize in a similar polymorphic form with nearly the same lamellar spacing; yet published lamellar X-ray diffraction intensity data for those materials do not agree with one another, even though the peak positions in Patterson maps are nearly the same. Translational structural searches based on the crystal structure of the race...

Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99:1 syn/anti and 99% ee.

Chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. Gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. Derivatives of spirooxindole find very wide biological applications as anti micr...