Additional Notes This guideline is intended to facilitate companies in compiling the dossier for submission for the replacement of a CFC propellant in an already authorised medicinal product. It identifies the considerations of quality, safety and efficacy which should be taken into account. The need for this guideline has been accentuated by the imminent lack of availability of existing replac...

Chlorofluorocarbons (CFCs) are currently used in systems for preservation of perishable foods and medical supplies, increasing worker productivity and consumer comfort, conserving energy and increasing product reliability. As use of CFCs is phased out due to concerns of ozone depletion, a variety of new chemicals and technologies will be needed to serve these needs. In choosing alternatives, in...

To investigate processes that might affect chlorofluorocarbon (CFC) mixing ratios at the water table, a time series was obtained of unsaturated zone soil gas CFCs to depths of ca. 4 m at a site near New York City (NYC). Observed CFC 11, 12, and 113 mixing ratios were lower in winter than expected from either a local, high-resolution time series or remote atmospheric mixing ratios. A diffusion m...

Nanostructured MoS2 is very promising as an electrocatalyst for hydrogen evolution due to a greater number of active edge sites. However, a very large resistance between basal planes decreases the overall efficiency of hydrogen evolution, and greatly limits its application in industry. Herein we develop a facile strategy to synergistically increase the number of active edge sites and the conduc...

It is a foreign-policy issue because, for a number of reasons, the United States has taken a more cautious approach to dealing with CO2 emissions than have many industrialized nations. Wide acceptance of the Montreal Protocol, which limits and rolls back the manufacture of chlorofluorocarbons (CFCs) to protect the ozone layer, has encouraged environmental activists at international conferences ...