Cloud point extraction was successfully applied to the preconcentration of phenothiazine derivatives, such as pericyazine (PC), chlorpromazine (CP) and fluphenazine (FUL), for gas chromatography (GC). Phenothiazine derivatives were separated from surfactants by passing the surfactant-rich phase through a cation exchange column after cloud point extraction, permitting the determination of the ph...

We propose chlorpromazine (CHP) as a new mediator for the rapid, sensitive, and highly selective voltammetric determination of homocysteine (Hcy) using multiwall carbon nanotube paste electrode (MWCNTPE). The experimental results showed that the carbon nanotube paste electrode has a highly electrocatalytic activity for the oxidation of Hcy in the presence of CHP as a mediator. Cyclic voltammetr...

The inhibition of protein synthesis in the brains of rats treated with chlorpromazine has been reported by Piha, Oja, and Usitalio (1) and by Glasky (2). In agreement with these observations, we were able to inhibit the incorporation of labeled amino acids into the brain proteins of mice by treating the animals with chlorpromazine. However, we were unable to demonstrate inhibition of the incorp...

Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) are principal mediators of septic shock; inhibition of TNF-alpha production may ameliorate outcome in severe infections. Pentoxifylline, chlorpromazine, and thalidomide inhibit TNF-alpha production. Their effects were tested in lethal endotoxemia in sensitized mice. Only chlorpromazine significantly improved survival. Ch...

Chlorpromazine is known to cause ocular pigmentary deposits. However, delayed presentation after cessation of chlorpromazine has not been reported. There are also no reports on whether newer generation of anti-psychotic agents contribute to ocular toxicity. We describe a case of ocular toxicity related to anti-psychotic agents. To the best of our knowledge, this is the first reported case of an...

BACKGROUND Chlorpromazine is a dopamine-receptor antagonist antipsychotic agent. Because of its strong alpha-blocking and sedative actions, it has also been used as emergency therapy for extreme arterial hypertension. Published reports to date have included very small numbers of patients (i.e., 5-30). OBJECTIVES To analyze data on almost 500 patients who received intravenous chlorpromazine fo...

Two newly isolated mutant strains of Neurospora crassa, cpz-1 and cpz-2, were hypersensitive to chlorpromazine with respect to mycelial growth but responded differently to the drug with respect to the circadian conidiation rhythm. In the wild type, chlorpromazine caused shortening of the period length of the conidiation rhythm. Pulse treatment with the drug shifted the phase and inhibited light...

IN the original publication on chlorpromazine, Courvoisier and her associates (1953) reported that this phenothiazine potentiated the intensity and duration of action of analgesic drugs in animals. They did not, however, show that chlorpromazine itself possessed any analgesic action. Schneider (1954) also found that it increased the duration of morphine analgesia in mice. Kopera and Armitage (1...

Chlorpromazine, a widely used tranquilizing drug of the phenothiazine group, was found to be a very potent photochemical inactivator of both deoxyribonucleic acid and ribonucleic acid viruses in the presence of long-wave ultraviolet light (320 to 380 nm). Neither the light alone nor chlorpromazine alone caused any appreciable inactivation. The known chlorpromazine photoreactions with nucleic ac...

The tumor-initiating ability of Agrobacterium tumefaciens was enhanced two- to threefold after a preinoculation exposure to the phenothiazine derivative chlorpromazine hydrochloride. The mean number of tumors initiated per viable bacterium on pinto bean leaves was greatest after a 1-hr exposure to 15 mug of the drug per ml. Chlorpromazine had no significant effect on tumor initiation when appli...