The relationship of riboflavin transport to the transport of other substances including drugs in rabbit choroid plexus, the anatomical locus of the blood-cerebrospinal fluid barrier, and brain cells were studied in vivo and in vitro. In vitro, the ability of rabbit choroid plexus to transport riboflavin from the medium (cerebrospinal fluid surface) through the choroid plexus epithelial cells in...

Banizs B, Komlosi P, Bevensee MO, Schwiebert EM, Bell PD, Yoder BK. Altered pHi regulation and Na /HCO3 transporter activity in choroid plexus of cilia-defective Tg737 mutant mouse. Am J Physiol Cell Physiol 292: C1409–C1416, 2007. First published December 20, 2006; doi:10.1152/ajpcell.00408.2006.—Tg737 mice have defects in cilia assembly and develop hydrocephalus in the perinatal period of lif...

Cerebellar granule cells, the most abundant neurons in the mammalian brain, arise in the rhombic lip located at the roof of the brain's fourth ventricle. Bordering the rhombic lip is the choroid plexus, a non-neuronal structure, composed of blood vessels enveloped by epithelial cells. Here, we show a striking decrease in neural differentiation of rhombic lip-derived cells, which failed to exten...

We identified immune complex deposits in the choroid plexus of approximately 75% of patients with acquired immunodeficiency syndrome (AIDS) who had either normal brains or human immunodeficiency virus encephalitis. Since circulating immune complexes are common in AIDS patients, and since local choroid plexus pathology usually was absent, their likely origin is from the bloodstream. Choroid plex...

In vitro, the transport of [14C]riboflavin into and from the isolated choroid plexus, the anatomical locus of the blood-cerebrospinal fluid barrier, was studied. With concentrations of [14C]riboflavin of 0.7 microM (or greater) in the incubation medium, the choroid plexus accumulated [14C]riboflavin against a large concentration gradient by a process that did not depend on binding or intracellu...

Ashton, J. C., I. Appleton, et al. (2004). "Cannabinoid CB1 receptor protein expression in the rat choroid plexus: a possible involvement of cannabinoids in the regulation of cerebrospinal fluid." Neurosci Lett 364(1): 40-2. Cannabinoid CB1 receptors in the brain are expressed on axon terminals presynaptic to neurons that express fatty acid amide hydrolase (FAAH). Postsynaptic FAAH catabolizes ...

Relatively few studies have been performed that analyze the morphology of the choroid plexus of the fourth ventricle. Due to the importance of this tissue as a landmark on imaging and during surgical intervention of the fourth ventricle, the authors performed a cadaveric study to better characterize this important structure. The choroid plexus of the fourth ventricle of 60 formalin fixed adult ...

The aim of this study was to quantitatively determine the constitutive expression levels of various transporter mRNAs in rat choroid plexus. To provide a reference for the relative expression levels, the expression of various transporter mRNAs in choroid plexus were compared with that in liver, kidney, and ileum. The mRNA levels of multidrug resistance protein (Mrp)1, 2, 3, 4, 5, and 6; multidr...

The choroid plexus, which is responsible for the maintenance of the biochemical milieu of the cerebrospinal fluid (CSF), avidly sequesters Pb. In order to test the hypothesis that chronic Pb exposure may impair choroid plexus function, male weanling Sprague-Dawley rats were exposed to Pb in drinking water at doses of 0, 50, or 250 micrograms Pb/ml (as Pb acetate) for 30, 60, or 90 days. The fun...

Congenital neoplasms of the choroid plexus are uncommon. A case of a surgically resected congenital third-ventricular choroid plexus papilloma is presented to demonstrate the appearance of this tumor using real-time sonography and MR imaging. The sonographic features of this tumor are reviewed and compared with previous reports . The MR characteristics are correlated with sonographic findings, ...