PURPOSE To assess and compare choroidal thickness changes related to aging, we determined whether changes are due to thinning of the choriocapillaris plus Sattler's (CS) layer and/or the large vessel layer in healthy eyes using swept-source optical coherence tomography (SS-OCT) at a wavelength of 1,050-nm. METHODS We studied 115 normal eyes of 115 healthy volunteers, all with refractive error...

AIMS To establish the characteristics of secondary retinal changes associated with the presence of choroidal melanomas and choroidal naevi as documented by optical coherence tomography (OCT). METHODS Twenty patients with untreated choroidal melanoma and 40 patients with presumed choroidal naevi managed by regular observation were included in the study. OCT scans across the surface of the tumo...

Choroidal melanoma is the most common primary intraocular malignancy in adults. Herein, authors report two cases of subretinal hemorrhage associated with it. The first case presented a large choroidal mass hemorrhage, no history trauma and diagnosis on ultrasound. second was initially diagnosed retinal detachment but during surgery pigmented observed, starting to bleed after scleral depression....

This clinico-pathological study has been carried out on benign and malignant choroidal melanomata with the following objects in view: (I) To find out the fluorescent pattern on fluorescence angiography which would distinguish a pigmented choroidal malignant melanoma from other lesions of similar appearance in the fundus of the eye, e.g. pigmented benign choroidal melanoma or nonneoplastic pigme...

Optical coherence tomography (OCT) plays an instrumental role in the diagnosis and follow-up of several retinal and choroidal diseases such as macular degeneration, vascular occlusion, and inflammation. Recently, OCT studies of intraocular tumors evaluated the intrinsic optical characteristics of choroidal tumors imaged using enhanced depth imaging OCT (EDI-OCT). Among body structures, the chor...

PURPOSE To analyze the topographic correlation between reticular pseudodrusen (RPD) visualized on infrared reflectance (IR) and choroidal vasculature using en-face volumetric spectral-domain optical coherence tomography (SD-OCT). METHODS A masked observer marked individual RPD on IR images using ImageJ (NIH, Bethesda, MD). Using the macular volume scan (Cirrus, Carl Zeiss Meditec Inc, Dublin,...

There is considerable debate about the significance of choroidal invasion of retinoblastoma with regard to metastatic disease. The charts of patients with retinoblastoma were reviewed over a 17 year period to determine the frequency of histopathological choroidal invasion of retinoblastoma and its risk for eventual metastatic disease. Sixty seven of 289 eyes (23%) enucleated for retinoblastoma ...

Angiogenesis inhibitors (e.g., ranibizumab, bevacizumab, pegaptanib, aflibercept) are being evaluated for the treatment of disorders of choroidal circulation. Ophthalmic disorders affecting the choroidal circulation include age-related macular degeneration (AMD), central serous chorioretinopathy (CSC), pathologic myopia, presumed ocular histoplasmosis syndrome, angioid streaks, idiopathic choro...

PURPOSE To evaluate choroidal thickness in young adults using enhanced-depth imaging spectral-domain optical coherence tomography and to describe volume differences in all the areas defined in the Early Treatment Diabetic Retinopathy Study. DESIGN Prospective clinical study. METHODS In 95 healthy young (23.8 ± 3.2 years) adult volunteers, 95 eyes were prospectively enrolled. Manual choroida...

Polypoidal choroidal vasculopathy has also been described in different pathological conditions including central serous chorioretinopathy(5), circumscribed choroidal hemangioma(6); melanocytoma of the optic nerve(7); pathological myopia and staphyloma(8); or choroidal osteoma(9). PCV seems to behave more like a neovasculopathy occurring in a variety of different diagnoses than a distinct abnorm...