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The cover shows the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE). PHF8 catalyzes hydroxylation of its H3 K9me2 substrate, EFE two competing reactions ethylene generation substrate l-Arg hydroxylation. Although both enzymes initially have an off-line 2-oxoglutarate (2OG) conformation, upon binding, forms in-line superoxo complex, whereas uses c...

This study explains the impression of MHD Maxwell fluid with presence thermal radiation on a heated surface. The heat and mass transmission analysis is carried out available Cattaneo–Christov dual diffusion. derived PDE equations are renovated into ODE use similarity variables. HAM technique implemented for finding solution. importance physical parameters velocity, temperature, concentration, s...

Methylation of arginine residues in histones is an important mechanism epigenetic regulation, and its dysregulation results human diseases such as cancer brain disorders. This study reveals the catalytic demethylation methylated R3 H4 histone by a non-heme Fe(II) 2-Oxoglutarate-Dependent Histone demethylase 4E (KDM4E). Applying QM/MM MD, we explored both C–H N–H activations pathways. Importantl...