Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the transcriptional inducibility of the tyrosine aminotransferase (TAT) gene by glucoc...

The role of the Drosophila lamin protein in nuclear envelope assembly was studied using a Drosophila in vitro assembly system that reconstitutes nuclei from added sperm chromatin or naked DNA. Upon incubation of the embryonic assembly extract with anti-Drosophila lamin antibodies, the attachment of nuclear membrane vesicles to chromatin surface and nuclear envelope formation did not occur. Lami...

Semiconservative DNA replication ensures the faithful duplication of genetic information during cell divisions. However, how epigenetic information carried by histone modifications propagates through mitotic divisions remains elusive. To address this question, the DNA replication-dependent nucleosome partition pattern must be clarified. Here, we report significant amounts of H3.3-H4 tetramers s...

background: methamphetamine (ma) is a potent psychomotor stimulant with high abuse and addictive potential. ma is a neurotoxic drug which is widely abused by females of childbearing age, raising serious public health concerns in terms of exposure of the fetus to the drug. neurotoxic effects of ma on adult are well known, such as dopaminergic nerve terminal degeneration and cell death in regions...

purpose : to evaluate the visual results of amblyopic therapy in pediatric patients with monocular abnormalities. methods : the hospital records of visually immature patients with unilateral organic ocular abnormalities and decreased visual acuity, who presented to the pediatric ophthalmology clinic over a one year period, were reviewed. those who had 8 years old of age or less and underwent am...

a study of the relationship between the disorder of glucose metabolism and ischemic heart disease was performed on 122 patients and 100 controls in loghman-dowleh adham’s medical center in tehran. the gtt abnormality was found in only 8% of the control group while for the patients with the heart ischemia the prevalence was 62.3%. prevalence of glucose metabolic disorder among men with acute myo...

objective: the aim of this study was to examine the efficiency of ha-binding test and sperm gradient processing method for the selection of sperm with normal protamine, intact dna and normal morphology. materials and methods: the study was conducted on 29 patients undergoing icsi. semen analysis was carried out according to who criteria. semen samples were divided into three equal portions. one...

objective: approximately 15-20% of clinically recognizable pregnancies end in spontaneous abortion. the incidence of chromosomal abnormalities in those abortions is as high as 50%.a modest but clinically important proportion of spontaneous abortions is caused by a balanced chromosomal aberration in one of the parents. this results from the production of gametes and embryos with unbalanced chrom...