Background: Sperm chromatin integrity assessment has been suggested as fertility predictor. The aim of this study was to examine the relationship between the results of sperm chromatin structure assay (SCSA) and the outcome of intrauterine insemination IUI. Materials and Methods: A total of 576 consecutive couples undergoing IUI were included and IUI was performed. SCSA results were expressed a...

in this study the effect of a methylated derivative of nitrogen mustard (mechloroethamin) on solubilized and reconstituted chromatin was investigated using uvnis spectroscopy, dna and sds gel electrophoresis and densitomeoic scanning techniques, the results indicated that the 210 and 260 nm absorbances of reconstituted chromatin were decreased in a dose-dependent manner after treatment with var...

Background: Chronic ethanol abuse causes reproductive organ failure and infertility in both humans and laboratory animals. Since sperm has a critical role in reproductive function, the objective of this unique study was to evaluate the effects of different doses of ethanol on sperm parameters, chromatin structure and apoptosis in adult mice. Materials and Methods: A total of 36 adult male mice ...

Higher-order chromatin structure and dynamics play a critical role in many aspects of gene regulation in eucaryotic cells. Therefore, a full understanding of chromatin organization and its functional significance is indispensable. Much is known about the primary and secondary level of chromatin structure. Not much information is available about the tertiary structure of chromatin domains, which...

Background The solid and colloidal particles in the range of 1-100 nm are called nanoparticles. Recently, one of the most important metal nanoparticles, with wide usage is gold nanoparticle. Based on the previous studies, gold nanoparticles have spermatotoxic effects and can destroy sperm motility. The aim of present study is the effect of gold nanoparticles on chromatin quality and sperm param...