UNLABELLED Ring chromosome aberration are rare abnormality potentially involving any chromosome in patients diagnosing in Oncology. The present review and case study has focused on the ring chromosome associated with oncology malignancies. MATERIAL AND METHODS An electronic peer review article search was performed systematically to obtain relevant literature with the CINAHL, Google scholar, a...

Background: Most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. However, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. Since FISH plays...

Cytogenetic analysis of hepatocellular carcinoma (HCC) cell lines and primary HCC tissues has demonstrated chromosome 1p to be the region most commonly affected. To refine the altered locus, genetic abnormalities of this region were surveyed systemically by microsatellite polymorphism analysis. Twelve sets of primers evenly distributed on chromosome 1p which can amplify di- or tetranucleotide r...

Chromosomal abnormalities are major causes of infertility, miscarriage and birth of handicapped progeny. In human live births, the prevalence of a chromosome aberration is ?0.5% and, of these, 0.1–0.3% correspond to structural chromosome rearrangements such as translocations, inversions, insertions and deletions .Our proband is an infant who had died 4 hours after birth due to a variety of abno...

background: most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. however, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. since fish plays...

Chromosome aberrations are large-scale illegitimate rearrangements of the genome. They are indicative of DNA damage and informative about damage processing pathways. Despite extensive investigations over many years, the mechanisms underlying aberration formation remain controversial. New experimental assays such as multiplex fluorescent in situ hybridyzation (mFISH) allow combinatorial "paintin...

Stevenson, Bedford, Dolphin, Purrott, Lloyd, Hill, Hill, Gumpel, Williams, Scott, Ramsey, Bruckner, and Fearn (1973) reported that high chromosome aberration yields in lymphocytes were found in those patients treated with injections of 198Au or 90Y for rheumatoid conditions ofthe knee when radioactivity had leaked along the lymphatics to the inguinal lymph nodes. This leakage and the consequent...

Irinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 microg mL-1), recommended monotherapy dose (9 microg mL-1), and recommended combined therapy dose (4.5 microg mL-1) of irinotecan were studied on V79 cells using the comet assay, chromosome aberration assay, and micronucleus test. ...

Phloxine is used as a food dye. In this study, genotoxicity of phloxine at the root tip Allium cepa L. was investigated. A. meristematic cells were treated with ten different doses phloxine. way, EC50 value determined. Then, applied to tips EC50/2, and EC50×2 doses. Treatment time determined 24, 48 72 hours. As result, it revealed that caused chromosomal aberrations in mitotic cycle cepa. There...