Neonatal Acute Kidney Injury (AKI) is characterized by a sudden decline in renal function, or failure of physiologic rise glomerular filtrate rate, leading to the kidneys' inability maintain fluid and electrolyte homeostasis.1,2 Despite significant attention given epidemiology acute kidney injury adult older paediatric populations, there paucity data on neonatal AKI. There has been notable lack...

Chronic patellar tendon rupture is a rare disabling injury that is technically difficult to repair. The true prevalence of this injury is unknown. Delayed reconstruction of chronic patellar tendon rupture has yielded suboptimal clinical and functional results. Many different surgical methods for reconstruction of chronic patellar tendon injury have been reported. In this report, we present a ca...

the initial experience concerning the use of magnetic resonance imaging in 94 patients who had sustained chronic cord injury showed its specific advantages over traditional imaging modalities. a variety of 84 cord abnormalities were identified including myelomalacia in 47%, cord cysts in 37%, focal atrophy in 11 % and cord transection in 5%. canal stenosis was seen in twenty-five patients, elev...

Transcatheter aortic valve replacement (TAVR) is an established therapy for patients with severe, symptomatic stenosis (AS). Post-procedural acute kidney injury (AKI) occurs in up to 20% of TAVR cases and associated increased mortality, particularly pre-existing chronic renal impairment.1,2 Chronic disease (CKD) has been worse clinical outcomes treated surgical AVRS1or TAVR.3 CKD promotes progr...

Inflammation is a major factor shaping outcome during the early, acute phase of traumatic spinal cord injury (SCI). It is known that pro-inflammatory signaling within the injured spinal cord drives pathological alterations in neurosensory processing and shapes functional outcome early after injury. However, it is unclear whether inflammation persists into the chronic phase of injury or shapes s...

Attentional biases to painful stimuli are evident in individuals with chronic pain, although the directional tendency of these biases (ie, toward or away from threat-related stimuli) remains unclear. This study used eye-tracking technology, a measure of visual attention, to evaluate the attentional patterns of individuals with and without chronic pain during exposure to injury-related and neutr...

Abstract Pulmonary arterial hypertension (PH), a progressive, incurable, and deadly disease, predominantly develops in women. Growing body of evidence suggest that dysregulated estradiol (E2) metabolism influences the development PH some biological effects E2 are mediated by its major non-estrogenic metabolite, 2-metyhoxyestradiol (2ME). The objective this study was to examine 2ME chronic hypox...

OBJECTIVE To describe the epidemiology of acute kidney injury, its relationship to chronic kidney disease, and the factors associated with its incidence. METHODS A cohort study and follow-up were conducted in an intensive care unit in Montevideo, Uruguay. We included patients admitted between November 2014 and October 2015 who were older than 15 years of age and who had at least two measureme...

Angiotensin II (AngII) causes hypertension (HTN) and promotes renal injury while simultaneously inducing reno-protective enzymes like heme oxygenase-1 (HO-1). We examined the modulatory role of HO on sub-pressor angiotensin II (SP-AngII) induced renal inflammation and injury. We first tested whether the SP-AngII-induced renal dysfunction, inflammation and injury are exacerbated by either preven...