Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (relative risk = 2.64, P less than 0.0002), acute myelogenous leukemia (relativ...

INTRODUCTION Osteoporosis in children is rare and usually secondary to an underlying disease process whose diagnosis may be difficult to detect. Etiological factors responsible for osteoporosis secondary to chronic illness include immobility, pubertal delay and other hormonal disturbances. Rarely, it can be a manifestation of acute lymphoblastic leukemia. Most of the reported bone fracture inci...

Terminal deoxynucleotidyl transferase (TdT) was determined by immunofluorescence in 30 patients with leukemia. In acute lymphocytic leukemia the proportion of cells positive for TdT was 19 to 77 percent during relapse (12 cases) and less than one percent during remission (three cases). In seven cases of myeloproliferative disease and two cases of lymphoma, the TdT was less than one percent. In ...

Using a radioimmunoassay, increased levels of a human thymus/leukemia-associated antigen (HThy-L) have been detected in leukemic cells and plasma from most patients with E-rosette-positive acute lymphoblastic leukemia (ALL) and a number of patients with E-rosette-negative ALL, acute myeloblastic leukemia (AML), acute monomyelocytic leukemia (AMML), and acute undifferentiated leukemia (AVL). Low...

Acute lymphoblastic leukemia is the most common malignancy in childhood. Continuous progress in risk-adapted treatment for childhood acute lymphoblastic leukemia has secured 5-year event-free survival rates of approximately 80% and 8-year survival rates approaching 90%. Almost 75% of survivors, however, have a chronic health condition negatively impacting on cardiovascular morbidity and mortali...

BACKGROUND Allogeneic hematopoietic cell transplantation is a potentially curative treatment for patients with acute lymphoblastic leukemia. However, the majority of older adults with acute lymphoblastic leukemia are not candidates for myeloablative conditioning regimens. A non-myeloablative preparative regimen is a reasonable treatment option for this group. We sought to determine the outcome ...

NUDT15 genetic variants and 6-mercaptopurine intolerance in pediatric acute lymphoblastic leukemia: an updated review

acute lymphoblastic leukemia (all) is one of the most common cancers among children. although there have been tremendous treatments, none of them have led to a precise cure. the use of herbal medicines which are safe and non-toxic have been demonstrated in this study. curcumin is a polyphenol, hydrophobic product that is derived from turmeric plant. curcumin has anti-toxic, anti-bacterial, anti...

nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...