We previously demonstrated that an acidic variant form of lysosomal arylsulfatase B accumulated in chronic myelogenous leukemia (CML) cells was highly phosphorylated at its carbohydrate moiety (Uehara Y. et al. Cancer Res 435618. 1983). Since lysosomal hydrolases including the sulfatase underwent the posttranslational phosphorylation processing at the carbohydrate moiety, we investigated two en...

A recently developed liquid culture technique was used to determine the proliferative and maturational character istics of leukemia cells from 7 patients with chronic myelogenous leukemia (CML). Marrow and blood leukocytes were cultured in an in vitro diffusion chamber for up to 45 days. Proliferation was assessed by viable cell counts and thymidine-3H-labeling indices. Maturation was determined

A recently developed liquid culture technique was used to determine the proliferative and maturational character istics of leukemia cells from 7 patients with chronic myelogenous leukemia (CML). Marrow and blood leukocytes were cultured in an in vitro diffusion chamber for up to 45 days. Proliferation was assessed by viable cell counts and thymidine-3H-labeling indices. Maturation was determined

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that follows a characteristic clinical course in which a chronic phase of variable duration precedes an accelerated, and ultimately blastic, phase, which is generally fatal. This disorder results from a clonal expansion of transformed hematopoietic progenitor cells and includes myeloid, monocytic, erythroid, megakaryocytic, and...

ECENTLY DEVELOPED technics for the study of chromosomes in peripheral blood and bone marrow cells have resulted in important discoveries in the field of cytogenetics. Recognition of numerical and morphologic changes following irradiation and the identification of a characteristic defect, the Ph’ chromosome, in human chronic myelogenous leukemia ( CML) have aroused speculation on the relationshi...

The term "leukemia" actually refers to a family of blood cancers, each having a distinct pattern of symptoms and cytology and each differing in age of onset, prognosis, and therapeutic options. The acute leukemias -acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL) -have been recognized for their rapid clinical progression when untreated and are diagnosed by the identificat...

isolated extramedullary relapse of chronic myelogenous leukemia (cml) after allogeneic stem cell transplant is rare. there is a case report of a child who developed a granulocytic sarcoma of the maxillary and sphenoid sinuses and lumbosacral spinal cord mass 18 months after allogeneic bone marrow transplant for cml. he was presented with per orbital edema and neurological deficit of lower extre...

Peripheral blood mononuclear cells from a patient with chronic myelogenous leukemia (CML), in remission, were depleted of CD8-positive T-cells and cultured with Epstein-Barr virus. Four of 20 cultures (20%) secreted human IgG antibodies selectively reactive with the cell surfaces of certain human leukemia cell lines. Three polyclonal, Epstein-Barr virus-transformed, B-cell lines were expanded a...

BACKGROUND EphA3 is a component of the Eph receptor family, the largest subgroup of the receptor tyrosine kinase (RTK) family. A recent array-based study implicated the presence of copy-number variations (CNVs) of EphA3 in the genomes of acute myelogenous leukemia. CNVs are present in the general population at varying degrees, and have been found to associate with various types of diseases incl...

ECENTLY DEVELOPED technics for the study of chromosomes in peripheral blood and bone marrow cells have resulted in important discoveries in the field of cytogenetics. Recognition of numerical and morphologic changes following irradiation and the identification of a characteristic defect, the Ph’ chromosome, in human chronic myelogenous leukemia ( CML) have aroused speculation on the relationshi...