BACKGROUND The use of a combination of different drugs in postoperative analgesia extends the time of analgesia, makes it more efficient and allows the use of lower drug doses, which leads to less risk of side effects and drug dependence. The aim of this study was to develop and validate an HPLC method to determine the stability of fentanyl citrate and bupivacaine hydrochloride mixtures in stan...

BACKGROUND There is ongoing controversy concerning optimum anticoagulation and buffering in continuous venovenous haemofiltration (CVVH). Regional anticoagulation with trisodium citrate also acting as a buffer in the replacement fluid has several advantages and disadvantages over prefilter citrate administration alone. We analysed a large cohort of patients with acute kidney injury (AKI) treate...

Many theories have been proposed to account for the accumulation of citrate in selected strains of Aspergillus niger (Berry et al., 1977). Citrate accumulation was attributed by Ramakrishnan et al. (1955) to loss of aconitase and isocitrate dehydrogenase activity, but the presence of these enzymes was clearly demonstrated by La Nauze (1966). The presence of tricarboxylic acid-cycle enzymes thro...

lead, copper, cobalt, nickel, iron and zinc ions form monocitrate complexes (negative charge) in citrate solution which is absorbed on the citrate form of anion-exchange resins (citrate as counter ion) y exchange of citrate ion with citrate complexes. these are subsequently recovered from the resin by 0.5m ammonium citrate eluent at ph 2.0. under optimized conditions, quantitative recovery was ...

A sensitive, fast, precise, reversed phasehigh performance liquid chromatography (RP-HPLC) method is developed for the determination of orphenadrine citrate in tablet dosage form. Linearity, precision, limit of detection (LOD), robustness and ruggedness, drug recovery and the system suitability parameters have been validated for the developed method. The HPLC conditions are methanol: acetonitri...