Like most areas of medicine, the clinical laboratory [clinical pathology (CP)] is seeing a rapid introduction of new technologies and science. New biomarkers for diagnosis, prognosis, prediction of response to therapy, and future risk are being proposed at such a high rate that it is difficult to keep up with the literature. At the same time, the aging population of the developed world will dem...

In humans, HHcy causes various symptoms such as mental retardation, epilepsy, epileptic seizures and atherosclerosis, whose pathology is not fully understood. Pro-inflammatory mediators released by activated microglia secrete various neurotoxic factors such as NO and ROS, which contribute to neuronal degeneration in neurodegenerative diseases [1,2]. Within this context, HHcy proved to cause neu...

This article looks at clinical governance and pathology. Clinical governance should be an important tool in seeking quality improvement within the National Health Service. But how as pathologists should we go about it?

Undeu the above comprehensive and indeed misleading title a very useful little pamphlet is published by Mr. R. Weiss, a consulting chemist, assisted by Dr. G. Herschell and Mr. A. Charles, F.R.C.S.i. It deals with the use of laboratory methods in daily practice. For example, 27 pages are given to urine analysis, another section to analysis of stomach contents, ten pages to analyses of faeces, a...

Using the "hole method," no inhibition could be demonstrated by the patient's sputum or serum, as the test is probably not delicate enough. X-ray report of antra and accessory air cells, 11th April, 1944 (five days after cessation of Penicillin treatment), shows nil abnormal. 0 X-ray chest (plate II), 11th April, 1944, report :-"Old infection of chest. Several heavily calcified foci on right si...