Sample size estimation is a necessary and crucial step in clinical trial research. Statistical requirements, limited patient availability high financial risk of necessitate the proper calculation this measure. The aim paper to discuss reasons why sample important and, based on obtained results, show how process may be completed selected cases. Stochastic simulations Monte Carlo methods approach...

n/a.

The specific goal of this (2nd edition) book continues to be to provide a comprehensive and unified presentation regarding sample size calculations in a variety of clinical research and development phases and to serve as a solid reference for researchers in academia, industry, and government. The book has been expanded, by around 100 pages, from its original 12 chapters to its current 15 chapte...

Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid-stream changes of sample size, endpoints, populations, etc. At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexi...