Variance estimators are derived for estimators of the average lead time and average benefit time due to screening in a randomized screening trial via influence functions. The influence functions demonstrate that these estimators are asymptotically equivalent to the mean difference, between the study and control case groups, in the survival times. For estimating benefit time, the survival time i...

In order to investigate the incidence, clinical and microbiologic characteristics of Clostridium difficile infection (CDI) in Korea, a prospective observational study was performed. From September 2008 through January 2010, all patients whose stool was tested for toxin assay A&B and/or C. difficile culture were studied for clinical characteristics. Toxin types of the isolates from stool were te...

of such a degree of hydrocephalus that there seems to be scarcely aiy brain substance left. In many cases of tuberculous meningitis streptomycin seems to maintain the condition of the patient when treatment was commenced, but little subsequent improvement is seen. Such experiences support the case for the inclusion of some adjuvant antibacterial agent with the streptomycin, in the hope that a s...

Observational studies are increasingly being used to estimate the effect of treatments, interventions and exposures on outcomes that can occur over time. Historically, the hazard ratio, which is a relative measure of effect, has been reported. However, medical decision making is best informed when both relative and absolute measures of effect are reported. When outcomes are time-to-event in nat...

Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that determine the dynamics of viral load within the human host, can inform investigators on the course and severity of infection and the efficacy of a nov...

BACKGROUND AND OBJECTIVE The estimation of dietary intake remains a challenge in human nutritional studies. In infants, the use of food diaries (FDs) is a suitable method already validated; however, this method is not exempt from error. In formula-fed infants, dilution of powdered formulas may produce errors. Our aim was to develop and validate standard operating procedures (SOPs) for the asses...

Early life adversity can have a significant long-term impact with implications for the emergence of psychopathology. Disruption to mother-infant interactions is a form of early life adversity that may, in particular, have profound programing effects on the developing brain. However, despite converging evidence from human and animal studies, the precise mechanistic pathways underlying adversity-...

Although the majority of adolescents report body dissatisfaction and the consequences of body image concerns are developmentally significant, most research addressing body image has been conducted by clinicians. Developmental scientists are in a unique position to contribute to body image research given their understanding of the intrapersonal (e.g., pubertal development) and interpersonal (e.g...

This pilot study compared the perceptions of beauty among Chinese women who were exchange students in the United States with Chinese women who were students in their homeland. We interviewed 19 women in China and 19 women in the United States to determine differences in responses. In accordance with the sociocultural approach and the social comparison approach, we expected Chinese women in the ...

Two new high field 2 T multipole wigglers have been built for the SRS. Detailed mechanical and magnetic tests have been made and these are compared with the expected theoretical performance. These insertion devices have now been installed into the SRS and are operating successfully.