نتایج جستجو برای: clinically isolated syndrome
تعداد نتایج: 1033495 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Vitamin D status has been associated with inflammatory activity in multiple sclerosis (MS), but it is not known if it is associated with gray matter volume, the loss of which predicts long-term disability in MS. The association of vitamin D levels with brain volume measures and inflammatory activity in patients with clinically isolated syndrome (CIS) was investigated. M...
A clinically isolated syndrome is the result of a single episode of demyelination in one area of the central nervous system (a monofocal episode) or several areas of the central nervous system (a multifocal episode) which lasts for at least 24 hours. Of those who are eventually diagnosed with MS, 85% experience an initial onset of symptoms or a first attack that is referred to as a clinically i...
We aim to determine if machine learning techniques, such as support vector machines (SVMs), can predict the occurrence of a second clinical attack, which leads to the diagnosis of clinically-definite Multiple Sclerosis (CDMS) in patients with a clinically isolated syndrome (CIS), on the basis of single patient's lesion features and clinical/demographic characteristics. Seventy-four patients at ...
BACKGROUND There is increasing evidence linking vitamin D deficiency to both susceptibility to, and severity of, multiple sclerosis (MS). Patients with the clinically isolated syndrome represent the initial presentation of a demyelinating disorder, and those with asymptomatic lesions on magnetic resonance imaging (MRI) are at risk of progression to clinically definite MS. The aims of this study...
AIM To investigate extent and nature of visual pathways involvement in children with clinically isolated syndrome (CIS). METHODS Forty-seven patients (age 11-17y) with CIS, which later proved to be multiple sclerosis (MS) onset, and 30 controls underwent visual evoked potentials (VEP) investigation within 12d from the appearance of the first signs of disease. Latency and amplitude of P100 pea...
Multiple sclerosis (MS) is a disease with heterogeneous evolution among the patients. Some classifications have been carried out according to either the clinical course or the immunopathological profiles. Epidemiological data and imaging are showing that MS is a two-phase neurodegenerative inflammatory disease. At the early stage it is dominated by focal inflammation of the white matter (WM), a...
OBJECTIVE To assess demographic, clinical, magnetic resonance imaging, and treatment exposure predictors of time to 3 or 12-month confirmed disability worsening in clinically isolated syndrome (CIS) and early multiple sclerosis (MS). METHODS We utilized the MSBase Incident Study (MSBasis), a prospective cohort study of outcome after CIS. Predictors of time to first 3 and 12-month confirmed ex...
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The pattern of cognitive abnormalities in multiple sclerosis (MS) has been extensively studied and well characterized. However, little is known about the cognitive involvement in patients with the clinically isolated syndrome (CIS). Objectives To perform a systematic review of the results of the studies on cognitive dysfunction in CIS patients. Methods Cochrane, Lilacs, PubMed/Medline and S...
Recently a group of community and academic neurologists gathered to discuss current topics of interest in multiple sclerosis (MS). The goal of the meeting was to provide an up-to-date review of the literature and to gather consensus opinions regarding key aspects of each of these topics. This article is the product of one of these sessions that focused on the initial clinical event suggestive o...
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