BACKGROUND Oral lichen planus (OLP) is considered to be an autoimmune disease of unknown aetiology that affects the mucosae, especially the oral cavity. OBJECTIVE We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointment for the treatment of OLP. PATIENTS AND METHODS A total of 32 patients (20 females and 12 males; all white, Italian origin, mean age of 43.6+/-18.4 years; 16 patien...

BACKGROUND Lichen sclerosus is a chronic, inflammatory skin condition that most commonly occurs in adult women, although it may also be seen in men and children. It primarily affects the genital area and around the anus, where it causes persistent itching and soreness. Scarring after inflammation may lead to severe damage by fusion of the vulval lips (labia); narrowing of the vaginal opening; a...

BACKGROUND Desquamative gingivitis (DG) is a clinical condition characterized by red, painful, glazed, and friable gingiva, which might be a manifestation of some autoimmune mucocutaneous diseases. The time from the development of initial signs of DG to diagnosis can vary from months to years. Based on a literature search, no data concerning patients with DG without signs of autoimmune disease ...

Abstract Objective: Glucocorticoid (GC) treatment suppress the hypothalamic-pituitary-adrenal axis, which may lead to tertiary adrenal insufficiency. This study aimed investigate prevalence of insufficiency among patients with oral lichen planus treated topical GC (clobetasol propionate) in cavity, a standard option for this condition. Methods: In cross-sectional study, we included 24 receiving...

Objective: Formulation and evaluation of clobetasol-17-propionate-loaded carboxymethyl chitosan nanoparticle. Psoriasis is a chronic skin disorder caused due to the autoimmune factors. It has detrimental psychological physiological impact on patients emergence apparent skin. The systemic therapy with anti-psoriatic drugs such corticosteroids, immunosuppressant, gene suppressors causes severe si...

Background: The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than half of marketed drugs. They share high structural substrate similarity are often studied together as CYP3A4/ 5. However, they preferentially different clinically prescribed Moreover, the differential distribution expression levels in both normal diseased tissues can aggravate toxicity induce resistance d...

Lichen nitidus is an uncommon skin condition that is clinically characterized by the presence of pinpoint papules, which are usually asymptomatic, flesh colored, with a flat, shiny surface. The histopathologic feature of it is characteristic. We report a 30-year-old man with typical skin lesions of lichen nitidus confirmed with histopathology, who also had multiple palmar pits. Treatment ...

INTRODUCTION We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). MATERIALS AND METHODS Two DM 0.25% formulations [ointment (DM-o) and fatty ointment (DM-fo, water...