نتایج جستجو برای: clock

تعداد نتایج: 47430  

Journal: :The International Conference on Electrical Engineering 2008

Journal: :IEEE Journal of Selected Topics in Quantum Electronics 2003

2003
Ming-Fu Hsiao Malgorzata Marek-Sadowska Sao-Jie Chen

Crosstalk noise is a crucial factor affecting chip performance in deep submicron technologies. Among all possible crosstalk noise sources, clock is the most common aggressor as well as victim..Crosstalk on clock nets can increase clock jitter, which may degrade significantly the system performance. It is therefore imperative to design clock buffers to reduce the coupling effects. In this paper,...

Journal: :Molecular cancer research : MCR 2010
Pia Alhopuro Mikael Björklund Heli Sammalkorpi Mikko Turunen Sari Tuupanen Mia Biström Iina Niittymäki Heli J Lehtonen Teemu Kivioja Virpi Launonen Juha Saharinen Kari Nousiainen Sampsa Hautaniemi Kyösti Nuorva Jukka-Pekka Mecklin Heikki Järvinen Torben Orntoft Diego Arango Rainer Lehtonen Auli Karhu Jussi Taipale Lauri A Aaltonen

The circadian clock regulates daily variations in physiologic processes. CLOCK acts as a regulator in the circadian apparatus controlling the expression of other clock genes, including PER1. Clock genes have been implicated in cancer-related functions; in this work, we investigated CLOCK as a possible target of somatic mutations in microsatellite unstable colorectal cancers. Combining microarra...

2013
Neelam R. Prakash

In this paper clock gating technique is presented for low power VLSI (very large scale integration) circuit design. Clock in digital circuits is used for synchronization of various components. Clock power is a major source of dynamic power consumed in synchronous circuits. Clock-gating is a well-known technique to reduce clock power. In clock gating clock to an idle block is disabled. Thus sign...

رضا منصوری, , محمدرضا خواجه‌پور, ,

  Einstein and transport synchronizations of infinitesimally spaced and distant clocks are considered in a general Riemannian space-time. It is shown that infinitesimally spaced clocks can always be synchronized. In general one can not find observers for whom distant clock are Einstein synchronized but transport synchronized observers do always exit. Whenever both procedures are possible, they ...

Journal: :Neuron 2006
Jason P. DeBruyne Elizabeth Noton Christopher M. Lambert Elizabeth S. Maywood David R. Weaver Steven M. Reppert

The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant circadian phenotypes. Surprisingly, CLOCK-deficient mice continue to express robu...

2017
Yan Xie Gerard J. M. Janssen Alle-Jan van der Veen

A clock synchronization scheme is crucial for obtaining accuracy in time-based positioning systems. Existing clock synchronization schemes are mostly based on a simplified linear clock model, which unfortunately have a poor long-term synchronization accuracy. Assuming a two-way time transfer protocol, we propose a novel clock synchronization algorithm based on a precise physical clock model to ...

Journal: :Cell 2006
Masao Doi Jun Hirayama Paolo Sassone-Corsi

The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay generates time-specific transcription of clock genes. The role of chromatin remodeling in a physiological setting such as the circadian clock is yet unclear. We show that the protein CLOCK, a central component of the circadian pacemaker, has histone acetyltransferase (HAT) activity. CLOCK shares homolo...

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