Two forms of Aspergillus niger 6-phosphofructo-1-kinase (PFK1) have been described recently, the 85-kDa native enzyme and 49-kDa shorter fragment that is formed from the former by posttranslational modification. So far, kinetic characteristics have never been determined on the enzyme purified to near homogeneity. For the first time, kinetic parameters were determined for individual enzymes with...

objective: the aim of this study is to determine if simvastatin pretreatment would change clomiphene response in clomiphene citrate-resistant (cc-r)women with (pcos). materials and methods: this quasi experimental study included twenty five clomiphene resistant women with pcos. all patients received cyclic oral contraceptives pills (ocp) (30µg of ethinyl estradiol and 150µg of desogestrol) from...

OBJECTIVE To compare the effectiveness of an electrocautery strategy with ovulation induction using recombinant follicle stimulating hormone in patients with polycystic ovary syndrome. DESIGN Randomised controlled trial. SETTING Secondary and tertiary hospitals in the Netherlands. PARTICIPANTS 168 patients with clomiphene citrate resistant polycystic ovary syndrome: 83 were allocated elec...

Metabolic acidosis has recently been observed in rat models of salt-sensitive genetic hypertension. To test the hypothesis that salt sensitivity in humans may be associated with abnormal acid-base homeostasis, we performed arterial blood gas analyses in young (20-31 years old) normotensive subjects (n = 40) who were placed on a low salt diet (20 mmol NaCl/day) for 2 weeks with either 200 mmol s...

There is an urgent need for better regimens to treat drug-resistant tuberculosis (DR-TB). Treatment for multi-drug resistant tuberculosis (MDR-TB, defined as resistance to both isoniazid and rifampicin) has a success rate of only 64% (Falzon et al., 2013), is prolonged for up to 24 months, and is poorly tolerated. Treatment success for extensively drug-resistant tuberculosis (XDR-TB, defined as...