This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be sufficiently effective. We study the flux of secondary electrons through the surface of nucleosomes and calculate the radial dose and the distribution of clust...

In cells exposed to ionizing radiation (IR), double-strand breaks (DSBs) form within clustered-damage sites from lesions disrupting the DNA sugar-phosphate backbone. It is commonly assumed that these DSBs form promptly and are immediately detected and processed by the cellular DNA damage response (DDR) apparatus. This assumption is questioned by the observation that after irradiation of naked D...

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2AX is a key step in facilitating efficient DSB repair, we investigated this process after localize...

The dynamical behaviors of a neural system are strongly influenced by its network structure. The present study investigated how the network structure influences decision-making behaviors in the brain. We considered a recurrent network model with four different topologies, namely, regular, random, small-world and scale-free. We found that the small-world network has the best performance in decis...

Image segmentation is the most challenging issue in computer vision applications. And most difficulties for crops management in agriculture are the lack of appropriate methods for detecting the leaf damage for pests’ treatment. In this paper we proposed an automatic method for leaf damage detection and severity estimation of coffee leaf by avoiding defoliation. After enhancing the contrast of t...

Cells of the neural stem cell lineage in the adult subventricular zone (SVZ) respond to brain insult by increasing their numbers and migrating through the rostral migratory stream. However, in most areas of the brain other than the SVZ and the subgranular zone of the dentate gyrus, such a regenerative response is extremely weak. Even these two neurogenic regions do not show extensive regenerati...