Biological activities of 17a-acetoxy-6-chloro-pregna-4,6-diene-3,20-dione (chlormadinone acetate ; CMA) were investigated in comparison with those of 17a-acetoxy-6a-methylpregnane-3,20-dione (medroxyprogesterone acetate ; MAP). CMA produced marked progestational activity either subcutaneously or orally in the uterine carbonic anhydrase test, and its relative potency is approximately 30 times th...

The application of staining with the guanine-cytosine specific fluorochrome chromomycin A3 (CMA) of citrus chromosomes to genetic studies is reviewed. When CMA staining is performed, the existence of characteristic CMA banding patterns with high levels of diversity and heterozygosity in citrus chromosomes is demonstrated. Similar CMA banding patterns have been observed in related species. Thus,...

Recently a dithered signed-error constant modulus algorithm (DSE-CMA) has been proposed for the purpose of low complexity implementation of constant modulus algorithm (CMA), which is widely used for blind adaptive filtering due to its LMS-like desirable robustness properties. Despite the fact that this algorithm has robustness properties closely resembling those of CMA, it is very slow in conve...

BACKGROUND Array Comparative Genomic Hybridization (a-CGH) is a powerful molecular cytogenetic tool to detect genomic imbalances and study disease mechanism and pathogenesis. We report our experience with the clinical implementation of this high resolution human genome analysis, referred to as Chromosomal Microarray Analysis (CMA). METHODS AND FINDINGS CMA was performed clinically on 2513 pos...

BACKGROUND AND OBJECTIVES Recent data suggest that cow's milk allergy (CMA) has become more persistent, prolonging treatment via strict elimination of cow's milk products into a period of skeletal growth. The objectives of this study were to compare bone mineral density (BMD), vitamin D status, and dietary intakes of calcium and vitamin D between prepubertal children with persistent CMA and tho...

Chaperone-mediated autophagy (CMA), a cellular process that contributes to protein quality control through targeting of a subset of cytosolic proteins to lysosomes for degradation, undergoes a functional decline with age. We have used a mouse model with liver-specific defective CMA to identify changes in proteostasis attributable to reduced CMA activity in this organ with age. We have found tha...

In this paper, we investigate the performance of CMA-ES on large scale non-separable optimisation problems. CMA-ES is a robust local optimiser that has shown great performance on small-scale nonseparable optimisation problems. Self-adaptation of a covariance matrix makes it rotational invariant which is a desirable property, especially for solving non-separable problems. The focus of this paper...

Aims. The CMa R1 star-forming region contains several compact clusters as well as many young early-B stars. It is associated with a well-known bright rimmed nebula, the nature of which is unclear (fossil HII region or supernova remnant). To help elucidate the nature of the nebula, our goal was to reconstruct the star-formation history of the CMa R1 region, including the previously unknown older...

A Stochastic Conjugate Gradient Algorithms (SCGA) is proposed for the solving nonlinear optimization problem assodated with the multi-nser constant modulus algorithm (CC-CMA) for DSCDMA receivers in a multi-user environment. The algorithm referred to as the stochastic conjngate gradient CC-CMA (SCGCC-CMA). Simulatious show that the SCGCCCMA algorithm preserves the fast convergence rate of the b...

This paper compares several Gaussian-processbased surrogate modeling methods applied to black-box optimization by means of the Covariance Matrix Adaptation Evolution Strategy (CMA-ES), which is considered state-of-the-art in the area of continuous black-box optimization. Among the compared methods are the Modelassisted CMA-ES, the Robust Kriging Metamodel CMAES, and the Surrogate CMA-ES. In add...