The Archimedes Tube Crystallizer (ATC) is a small-scale coiled tubular crystallizer operated with air-segmented flow. As individual liquid segments are moved through the apparatus by rotation, ATC operates as pump. Thus, overcomes pressure drop limitations of other continuous crystallizers, allowing for longer residence times and crystal growth phases. Understanding phenomena basis well-designe...

This article presents a model-based control approach for optimal operation of a seeded fed-batch evaporative crystallizer. Various direct optimization strategies, namely, single shooting, multiple shooting, and simultaneous strategies, are used to examine real-time implementation of the control approach on a semi-industrial crystallizer. The dynamic optimizer utilizes a nonlinear moment model f...

The studies on the resistance to degradation of capillary polypropylene membranes assembled in a membrane crystallizer were performed. The supersaturation state of salt was achieved by evaporation of water from the NaCl saturated solutions using membrane distillation process. A high feed temperature (363 K) was used in order to enhance the degradation effects and to shorten the test times. Salt...

In this work, we focus on the development and application of predictive-based strategies for control of particle size distribution (PSD) in continuous and batch particulate processes described by population balance models (PBMs). The control algorithms are designed on the basis of reduced-order models, utilize measurements of principle moments of the PSD, and are tailored to address different c...

Increasing global competition, volatile markets and the demand for individual products challenge companies in almost all business sectors require innovative solutions. In chemical pharmaceutical industries, these include modular design, integration of several unit operations one apparatus development small-scale, versatile multipurpose plants. An example such a modular, integrated small-scale s...

The optimal batch control of a multidimensional crystallization process is investigated. A high resolution algorithm is used to simulate the multidimensional crystal size distribution under the operations defined by two optimal control trajectories. It is shown that a subtle change in the optimal control objective can have a very large effect on the crystal size and shape distribution of the pr...

The aim of this study was to examine the effect of Takusha (Alismatis rhizoma), a Kampou medicine, on the formation, growth and aggregation of calcium oxalate (CaOx) crystals by a seed crystal system, an undiluted urine system and a continuous flow crystallizer system. In the seed crystal method using a metastable solution, the inhibitory effect on aggregation and growth of CaOx crystals was ca...