نتایج جستجو برای: cng tank
تعداد نتایج: 15565 فیلتر نتایج به سال:
Proper control of intracellular free Ca(2+) is thought to involve subsets of proteins that co-localize to mediate coordinated Ca(2+) entry and Ca(2+) extrusion. The outer segments of vertebrate rod and cone photoreceptors present one example: Ca(2+) influx is exclusively mediated via cGMP-gated channels (CNG), whereas the Na(+)/Ca(2+)-K(+) exchanger (NCKX) is the only Ca(2+) extrusion protein p...
Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sino-atrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in X...
Cyclic nucleotide-gated (CNG) channels are a family of ion channels activated by the binding of cyclic nucleotides. Endogenous channels have been used to measure cyclic nucleotide signals in photoreceptor outer segments and olfactory cilia for decades. Here we have investigated the subcellular localization of cGMP signals by monitoring CNG channel activity in response to agonists that activate ...
Nonmotile cilia on olfactory sensory neurons (OSNs) compartmentalize signaling molecules, including odorant receptors and cyclic nucleotide-gated (CNG) channels, allowing for efficient, spatially confined responses to sensory stimuli . Little is known about the mechanisms of the ciliary targeting of olfactory CNG channels, composed of three subunits: CNGA2, CNGA4, and CNGB1b . Recent reports su...
The cGMP sensitivity of cyclic nucleotide-gated (CNG) channels can be modulated by changes in phosphorylation catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases. Previously, we used genistein, a PTK inhibitor, to probe the interaction between PTKs and homomeric channels comprised of alpha subunits (RETalpha) of rod photoreceptor CNG channels expressed in Xenopus oocy...
Quentin Skinner is an intellectual historian known for his pioneering work on early-modern European political thought. He was educated at Bedford School and Gonville and Caius College, Cambridge. Author of such works as The Foundations of Modern Political Thought (1978) and Visions of Politics (2002) he served as the Regius Professor of History at the University of Cambridge, and currently as t...
403 C o m m e n t a r y In this issue, Dai et al. present an investigation of the biophysics of phosphatidylinositide (PIP) regulation of the cyclic-nucleotide gated (CNG) channels expressed in cone photoreceptors. Although PIPs facilitate or stabilize the activation of many other types of ion channels , they strongly inhibit the response to cAMP or cGMP (collectively, cNMP) of CNG channels. Pr...
استفاده از گاز طبیعی فشرده به عنوان سوختی پاک در سراسر دنیا در حال افزایش است. با رشد روزافزون وسایل نقلیه در ایران و به دلیل بالابودن هزینههای احداث جایگاههای CNG، مکانیابی مناسب و بهینه این جایگاهها از اهمیت ویژهای برخوردار است. مدل مکانیابی جریان سوختگیری یکی از مدلهایی است که اخیراً به منظور مکانیابی جایگاههای سوخت مطرح شده است. در این تحقیق جایگاههای سوخت CNG در دو مسیر برونشه...
PURPOSE FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical trials. This study explores FGFR1 mRNA and protein levels in HNSCC cell lines, primary tumors, and patient-derived xenografts (PDX) as predictors of sensitivity to the FGFR inhibitor, NVP-BGJ398. EXPERIMENTAL DESIGN FGFR1 status, expr...
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