Isolated central nervous system (CNS) relapse of non-Hodgkin lymphoma (NHL) is very rare. We report a five-year-old boy with T-cell lymphoblastic lymphoma (T-LBL), who developed CNS relapse under treatment when the primary tumor was in complete remission. The patient presented initially with persistent cough and an anterior mediastinal mass and had no bone marrow or CNS involvement at diagnosis...

Factors contributing to the development of central nervous system (CNS) leukemia, and the impact of leukemic involvement of this site on subsequent remission length, were determined in 184 children with acute nonlymphoblastic leukemia who had been treated in two successive clinical trials. Preventive CNS therapy in both studies consisted of intrathecal methotrexate (12 mg/m2) given monthly duri...

BACKGROUND To describe incidence, risk factors, and influence of treatment on occurrence of central nervous system (CNS) relapse or progression in younger patients with aggressive B-cell lymphoma. PATIENTS AND METHODS We analyzed 2210 patients with aggressive B-cell lymphoma treated on various studies for CNS relapse/progression. Treatment consisted of CHOP (cyclophosphamide, doxorubicin, vin...

A 42-year-old female was diagnosed with acute promyelocytic leukemia (APL) with a translocation of chromosomes 15 and 17 involving the PML and RARA genes. On presentation she met criteria for low-risk disease on the basis of platelet count (50 10/L) and WBC count (0.8 10/L). The patient achieved a complete molecular remission after induction chemotherapy with all-trans-retinoic acid (ATRA) and ...

BackgroundThere is rising concern on the impact of new strategies, such as high-dose chemotherapy (HDC) and immunotherapy, pattern relapse in high-risk neuroblastoma (HR-NBL). Our aim to evaluate incidence identify risk factors for first recurrence central nervous system (CNS) HR-NBL.Patients methodsData from patients with stage 4V HR-NBL included February 2002 June 2015 prospective trial Europ...

Central nervous system (CNS) relapse affects 5% of diffuse large B-cell lymphoma (DLBCL) patients and portends a poor prognosis. Prophylactic intravenous high-dose methotrexate (HD-MTX) is frequently employed to reduce this risk, but there limited evidence supporting practice. We conducted multicenter retrospective study determine the CNS risk with HD-MTX in DLBCL aged 18–70 years treated Alber...

Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosis in children. While current treatment has greatly improved survival rates, relapse occurs in 15-20% of patients. Signs and symptoms are similar to those found at initial presentation. However, in some patients, relapse can occur in the central nervous system (CNS), even if they did not have previous CNS involvement. Many case...

abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. we report an 11 years old girl who developed central hypothyroidism and acth deficiency during the chemotherapy for cns relapse of acute lymphoblastic leukemia before receiving radiotherapy. keywords: thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leuk...