The aim of the study was to evaluate the effect of two antithrombotic therapies on platelet function and on coagulation in patients with nonvalvular atrial fibrillation (NVAF). Twenty patients with NVAF were treated with aspirin (300 mg/day) and clopidogrel (75 mg/day) for 2 weeks immediately followed by oral anticoagulation (target international normalized ratio 2.0-3.0). Parameters of platele...

BACKGROUND Intraoperative cardiovascular deterioration as a result of pulmonary embolization of bone marrow fat is a potentially serious complication during vertebroplasty. The release of fatty material and thromboplastin from the bone marrow cavity during vertebroplasty may activate the coagulation cascade resulting in thrombogenesis, and pharmacological prophylaxis may therefore prevent cardi...

BACKGROUND Development of hydroxyethyl starches (HES) with a low impact on blood coagulation but a long intravascular persistence is of clinical interest. A previous in vitro study showed that low substituted high molecular weight HES does not compromise blood coagulation more than medium molecular weight HES. In the present study we assessed the individual effects on blood coagulation of molar...

BACKGROUND Rejecting hemolyzed specimens received for coagulation studies is advised by the Clinical and Laboratory Standards Institute. Receiving such specimens is a common phenomenon in many laboratories. The true impact of hemolysis on coagulation studies is little studied in clinical practice. AIM The aim of this work is to study the changes occurring in readings of prothrombin time (PT) ...

Abstract The use of high-frequency (HF) generators for HF surgical treatment biological tissue has become an indispensable part today's applications all kinds. Generally, alternating electric currents between 300 kHz and 1 MHz are used to induce hemostasis by heating at the cellular level. This effect can be attributed Joule heating, in which a current dissipated conductor converts electrical e...