Colicin endonucleases (DNases) are bound and inactivated by immunity (Im) proteins. Im proteins are broadly cross-reactive yet specific inhibitors binding cognate and non-cognate DNases with K(d) values that vary between 10(-4) and 10(-14) M, characteristics that are explained by a 'dual-recognition' mechanism. In this work, we addressed for the first time the energetics of Im protein recogniti...

The present study examined effects of cross-linguistic overlap and language proficiency on bilingual parallel language activation. Recognition of cognates (e.g., English hen, German Henne) was compared to recognition of non-cognates (e.g., English bike, German Fahrrad) in English-German bilinguals, German-English bilinguals, and monolinguals. In an eye-tracking paradigm, participants identified...

There is a growing body of evidence showing that a word's cognate status is an important dimension affecting the naming performance of bilingual speakers. In a recent article, Kohnert extended this observation to the naming performance of an aphasic bilingual (DJ). DJ named pictures with cognate names more accurately than pictures with non-cognate names. Furthermore, having named the pictures i...

Increased expression of the CCU/CCA/CCG-decoding tRNA(Pr)(o)3 on a multicopy plasmid leads to suppression of several +1 frameshift mutations in Salmonella enterica serovar Typhimurium. Systematic analysis of the site of frameshifting indicates that excess tRNA(Pr)(o)3 promotes near-cognate decoding at CCC codons. Re-phasing of the reading frame can be achieved by a subsequent slippage of the tR...

If the enzymes responsible for biosynthesis of a given amino acid are repressed and the cognate amino acid pool suddenly depleted, then derepression of these enzymes and replenishment of the pool would be problematic, if the enzymes were largely composed of the cognate amino acid. In the proverbial "Catch 22", cells would lack the necessary enzymes to make the amino acid, and they would lack th...

The ribosome selects aminoacyl-tRNA (aa-tRNA) matching to the mRNA codon from the bulk of non-matching aa-tRNAs in two consecutive selection steps, initial selection and proofreading. Here we report the kinetic analysis of selection taking place under conditions where the overall selectivity was close to values observed in vivo and initial selection and proofreading contributed about equally. C...

This study examined the role of phonological and orthographic overlap in the recognition of cognate words by recording electrophysiological and behavioral data. One hundred and ninety-two words were selected: 96 cognate words listed according to their phonological and orthographic overlap vs. 96 noncognate words. Twenty-four proficient European Portuguese-English bilinguals performed a silent r...

Abstract Research in second language (L2) learning often considers one modality only during task completion. It is unclear if L2 performance as accurate whatever the modality. at school characterized by a predominance of written materials. One might expect word recognition to be more than spoken one. This effect could also depend on proficiency and presence cognate items, closer orthographicall...